雷贝拉唑、铋剂三联疗法对溃疡性和非溃疡性消化不良根除幽门螺杆菌差异性研究

目的 研究雷贝拉唑、铋剂三联疗法对溃疡性和非溃疡性消化不良根除幽门螺杆菌(HP)的差异性及再复发率,并探讨年龄、服用非甾体消炎药(NSAIDs)、吸烟等对HP根除率的影响.方法 利用雷贝拉唑三联(雷贝拉唑、克拉霉素、阿莫西林)、铋剂三联(胶体次橼酸铋、克拉霉素、阿莫西林)对70例非溃疡性消化不良患者和99例溃疡性患者根除HP,停药一月后复查C-14呼气试验,以了解HP是否根除,一年后再复查C-14呼气试 验,以明确有无再感染.结果 对溃疡性和非溃疡性消化不良患者,两种方案的根除率无明显差异,但雷贝拉唑三联疗法根除率高于铋剂三联疗法.服用NSAIDs、吸烟、年龄与HP根除率有一定相关性.结论 采用雷贝拉唑三联根除HP,可提高根除率及降低再感染的可能性.在根除HP过程中,要尽量不吸烟,避免服用NSAIDs.

The study on difference between two Helicobacter pylori eradication treatments for patients with peptic ulcer disease and non-ulcer dyspepsia

Objective This study dicussed whether patients with non-ulcer dyspepsia respond differently to H Pylori eradication than with peptic ulcer disease, different reinfection between them and the relations with the age, NSAIDs, smoking, and so on. Methods Rabeprazole-containing triple regiments (Rabeprazole, Clarithromycin and Amoxicilin) and RBC-containing triple regiments (ranitidine bismuth citrate, Amoxicilin and Clarithromycin) are carried for 70 patients with non-ulcer dyspepsia and 99 patients with peptic ulcer disease. C14-UBT test are carried after a month and a year when stop taking medicine in order to learn whether HP are eradicated or there are recurrence. Results No significant difference was found between two HP eradication treatments for patients with non-ulcer dyspepsia and peptic ulcer disease. But LCA is more effective than RCA. The eradication rate of HP are related with NSAIDs, smoking, age. Conclusions Two treatments are both effective in HP eradicationl. But the LCA has higher rate eradication and lower reinfection rate.