注射不同针次和剂量乙肝免疫球蛋白预防乙肝病毒宫内感染

目的观察不同针次和剂量乙肝免疫球蛋白(HBIG)预防乙肝病毒(HBV)宫内感染。方法从湘潭市妇幼保健院病案室选取2008年6月-2011年6月产科筛查出无症状携带乙型肝炎表面抗原(HBsAg)孕妇及其所生新生儿各135例。随机分为3组,即对照组、HBIG阻断A组和HBIG阻断B组,每组各45例。检测新生儿血清中HBsAg和HBeAg水平。结果 HBIG治疗组(A和B)新生儿宫内感染率为14.4%,对照组为37.8%,前者明显低于后者(P<0.05)。HBIGA组双阳性母亲的新生儿宫内感染率(35.7%)低于对照组(100%),HBIG B组(64.5%)低于对照组,但差异无统计学意义。结论按照HBV不同携带状态使用两种不同剂量的HBIG,更利于对HBV母婴传播的阻断。

Effectiveness of Injection of Different times and Doses of HBIG on Preventing Mother - to- Child HBV Transmission During Pregnancy

Objective To observe the effectiveness of different immunization procedures and different doses of hepatitis B immune globulin(HBIG) on blocking HBV intrauterine transmission.Methods One hundred and thirty-five pregnant women,who were diagnosed with positive hepatitis B surface antigen(HBsAg) in Department of Obstetrics,Maternal and Child Health Hospital of Xiangtan City from June 2008 to June 2011,were selected as the study objects.They were randomly divided into 3 groups: control group and two HBIG blocking groups(groups A and B),(each n=45).Blood specimens of all neonates were tested for HBsAg and HBeAg by enzyme immunoassay.Results The rate of HBV intrauterine infection in groups A and B(14.4%) was significantly lower than that in control group(37.8%),(P<0.05).The rate of HBV intrauterine infection of newborns from HBsAg and HBeAg double-positive mother in group A(35.7%) was lower than that of control group(100%),and the rate of group B(64.5%) was also lower than that of control group,but no statistically significant difference was found between the two groups.Conclusions HBV infection in the uterus may be interrupted by injecting intramuscular HBIG injections before delivery,and more efficacy may be found using various HBIG doses according to different HBV viremia.