女性泌尿生殖道炎症患者支原体感染现状及其对抗生素的敏感性研究

目的了解女性泌尿生殖道炎症患者支原体的感染现状及其对抗生素的敏感性。方法回顾性分析清苑县妇幼保健院2010年1月-2011年8月收治的女性泌尿生殖道炎症患者560例的临床资料,支原体感染254例,对该254例泌尿生殖道炎症患者做体外支原体培养鉴定及药物敏感试验。结果支原体感染阳性率为45.4%。单纯解脲脲原体(Uu)感染率为63.8%(162/254),明显高于单纯人型支原体(Mh)及Uu+Mh混合感染率9.5%(24/254)、26.8%(68/254),组间差异有统计学意义(P<0.05)。单纯Uu感染对克拉霉素、交沙霉素敏感,Uu与Mh混合感染者对强力霉素敏感,单纯Mh感染对强力霉素敏感。结论本院女性泌尿生殖道炎症患者支原体的感染以单纯Uu感染为主,不同生物型支原体感染对抗生素敏感率不同,临床医师应根据支原体的感染现状及其对抗生素的敏感性选用合适的抗生素。

Study on Current Status of Mycoplasma Infection and Sensitivity to Antibiotics in Female Patients with Inflammation of Genitourinary Tracts

Objective To investigate the current situations of mycoplasma infection and sensitivity to antibiotics among female patients with inflammation of genitourinary tracts. Methods The clinical data of 560 female patients with inflammation of genitourinary tracts hospitalized in the Maternal and Child Health Hospital of Qingyuan County from January 2010 to August 2011 were analyzed retrospectively. In vitro mycoplasma culture identification and drug sensitivity testing were done for 254 patients with mycoplasma infection. Results The tx~sitive rate of mycoplasma infection was 45.4 %. The infection rate of simple Ureaplasma urealyticum （Uu） was 63.8% （162/254）, which was significantly higher than those （9.5%, 24/254; 26.8 %, 68/254） of simple Mycoplasma hominis （Mh） infection and Uu ＋ Mh mixed infection, and there were statistically significant differences between the two groups （P〈0. 05）. Simple Uu infection was sensitive to clarithromycin and josamycin. Uu ＋ Mh mixed infection and simple Mh infection were both sensitive to doxycycline. Conclusions Simple Uu infection dominated over myeoplasma infection in female patients with inflammation of genitourinary tracts in this hospital, and different bio- types of mycoplasma infection showed different antibiotic susceptibility rates. Clinicians should select appropriate antibiotics based on the status of mycoplasma infection and its sensitivity to antibiotics.