主动免疫治疗加用地屈孕酮治疗复发性流产的临床观察

目的探讨淋巴细胞主动免疫治疗加用地屈孕酮治疗复发性流产的临床疗效观察。方法 2008年3月-2011年3年将70例有复发性流产患者被随机分为两组,35名要求接受淋巴细胞主动免疫治疗和地屈孕酮的患者为观察组,35名接受地屈孕酮的患者为对照组;检测两组患者血清E2、P和HCG水平,以评估治疗结果,记录妊娠结果进行统计学分析。结果两组在年龄、孕次、产次、前次自然流产时间方面差异无统计学意义（P〉0.05）;两组在血清E2、P和HCG的水平在8周前及8～12周差异均无统计学意义（P〉0.05）。妊娠情况：淋巴细胞主动免疫治疗和地屈孕酮组35例,足月妊娠分娩成功34例（97.1%）,地屈孕酮组35例,足月妊娠分娩27例（77.1%）,两组相比差异有统计学意义（P〈0.05）。结论淋巴细胞主动免疫治疗加用地屈孕酮可以明显提高复发性流产患者的继续妊娠率。

Clinical Observation on Curative Effect of Active Immunotherapy Combined with Dydrogesterone on Recurrent Spontaneous Abortion

Objective To explore the clinical efficacy of lymphocytes active immunotherapy combined with dydrogesterone on treating recurrent spontaneous abortion.Methods Seventy patients with recurrent spontaneous abortion were randomly divided into two groups(each n=35).The patients in observation group were given active immunotherapy combined with dydrogesterone,while the patients in control group received dydrogesterone.Serum E2,P,and HCG levels of the patients of two groups were detected to evaluate the treatment outcomes.The pregnancy results were recorded and then analyzed statistically.Results There was no statistically significant difference in age,pregnancies,parity,and spontaneous abortion time between the two groups(P>0.05).And no statistically significant difference was found in serum E2,P,and HCG levels before 8 weeks or between 8 to 12 weeks(P>0.05).Among 35 patients of observation group,34(97.1%) succeeded in giving full-term birth.Among 35 patients of control group,27(77.1%) succeeded in giving full-term birth.There were statistically significant differences between the two groups(P<0.05).Conclusions Lymphocytes active immunotherapy combined with dydrogesterone can significantly improve the ongoing pregnancy rate in patients with recurrent spontaneous abortion.