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Tissue inhibitor of metalloproteinase-1 protects MCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1 |
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| Authors: | Wang T Lv JH Zhang XF Li CJ Han X Sun YJ Nanjing Med Univ Key Lab Human Funct Genom Jiangsu Prov Nanjing Peoples R China Nanjing Med Univ Dept Cell Biol & Med Genet Nanjing Univ Sch Med Nanjing Ctr Canc |
| Institution: | Wang,T,Lv,JH,Zhang,XF,Li,CJ,Han,X,Sun,YJ Nanjing Med Univ,Key Lab Human Funct Genom Jiangsu Prov,Nanjing 210029,Peoples R China,Nanjing Med Univ,Dept Cell Biol & Med Genet,Nanjing Univ,Sch Med,Nanjing 210008,Ctr Canc |
| Abstract: | Paclitaxel(PTX) is a very effective drug in treating tumors.It disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis,leading to cell death by apoptosis.However,the effectiveness of PTX in cancer chemotherapy is hampered by drug resistance in some patients.Tissue inhibitor of metalloproteinase-1(TIMP-1) is well known to be capable of inhibiting apoptosis.Elevated tumor tissue TIMP-1 levels have been significantly associated with a poor response to chemotherap... |
| Keywords: | TIMP-1 PTX apoptosis cyclin B1 breast cancer |
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