Characterization of mechanisms of resistance to beta-lactam antibiotics in methicillin-resistant strains of Staphylococcus saprophyticus. |
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| Authors: | C W Stratton M S Gelfand J L Gerberding H F Chambers |
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| Affiliation: | Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2561. |
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| Abstract: | The resistance mechanisms of methicillin-resistant strains of Staphylococcus saprophyticus were characterized. Penicillin-binding protein (PBP) studies demonstrated an inducible PBP identical to PBP 2a in the membranes of these isolates. The amount of beta-lactamase produced was minimal. PBP 2a is responsible for the methicillin resistance observed in these strains of S. saprophyticus. |
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