X chromosomal regulation in flies: when less is more |
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Authors: | Erinc Hallacli Asifa Akhtar |
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Institution: | (1) Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany;(2) Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany; |
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Abstract: | In Drosophila, dosage compensation of the single male X chromosome involves upregulation of expression of X linked genes. Dosage compensation
complex or the male specific lethal (MSL) complex is intimately involved in this regulation. The MSL complex members decorate
the male X chromosome by binding on hundreds of sites along the X chromosome. Recent genome wide analysis has brought new
light into X chromosomal regulation. It is becoming increasingly clear that although the X chromosome achieves male specific
regulation via the MSL complex members, a number of general factors also impinge on this regulation. Future studies integrating
these aspects promise to shed more light into this epigenetic phenomenon. |
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Keywords: | |
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