Systemic and intrabasalis administration of the orexin-1 receptor antagonist,SB-334867, disrupts attentional performance in rats |
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| Authors: | Karen E Boschen Jim R Fadel Joshua A Burk |
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| Institution: | (1) Department of Psychology, College of William & Mary, Williamsburg, VA 23187, USA;(2) Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA; |
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| Abstract: | Rationale Orexin neurons project to a number of brain regions, including onto basal forebrain cholinergic neurons. Basal forebrain corticopetal
cholinergic neurons are known to be necessary for normal attentional performance. Thus, the orexin system may contribute to
attentional processing. |
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