Biological aspects of angiogenesis in multiple myeloma |
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Authors: | Eléonore Otjacques Marilène Binsfeld Agnes Noel Yves Beguin Didier Cataldo Jo Caers |
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Affiliation: | 1.Laboratory of Hematology, GIGA-Research,University of Liège,Sart-Tilman,Belgium;2.Laboratory of Tumor and Development Biology, GIGA-Research,University of Liege,Sart-Tilman,Belgium;3.Department of Clinical Hematology,Centre Hospitalier Universitaire de Liège,Liège,Belgium |
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Abstract: | Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant expansion of malignant plasma cells within the bone marrow (BM). One of the hallmarks of this disease is the close interaction between myeloma cells and neighboring cells within the BM. Angiogenesis, through the activation of endothelial cells, plays an essential role in MM biology. In the current review, we describe the angiogenesis process in MM by identifying the interacting cells, the pro- and anti-angiogenic cytokines modulated, and the extracellular matrix degrading proteases liable to participate in the pathophysiology. Finally, we highlight the impact of hypoxia (through hypoxia-inducible factor-1) and constitutive activation of nuclear factor-κB in this tumor-induced neo-vascularization. |
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