rhBMP-2 not alendronate combined with HA-TCP biomaterial and distraction osteogenesis enhance bone formation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

rhBMP-2 not alendronate combined with HA-TCP biomaterial and distraction osteogenesis enhance bone formation

Authors:	Ming Ni Gang Li Pei-Fu Tang Kai-Ming Chan Yan Wang

Affiliation:	(1) Department of Orthopaedic Surgery, General Hospital of Chinese People’s Liberation Army, Beijing, 100853, People’s Republic of China;(2) Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University Hong Kong, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, People’s Republic of China;(3) Stem Cells and Regenerative Program, School of Biomedical Sciences, The Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People’s Republic of China;(4) CUHK-WHO Collaborating Centre for Sports Medicine and Health Promotion, The Chinese University Hong Kong, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, People’s Republic of China;

Abstract:	Introduction The long treatment duration of distraction osteogenesis (DO) usually causes some complications such as re-fracture, non-union. We have previously demonstrated that the combined use of biomaterial with distraction osteogenesis technique can enhance bone formation and consolidation. This study further tested whether the use of biological agents such as rhBMP-2 or alendronate together with biomaterials in DO will further promote bone formation.

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Introduction