剖宫产手术对机体细胞免疫及体液免疫功能影响的研究

目的：探讨剖宫产手术对机体细胞免疫与体液免疫的影响。方法：对67例接受剖宫产者的外周血T淋巴细胞亚群（CD3、CD4、CD8、CD4／CD8比值）及IgG,IgA,C－反应蛋白（CRP）含量于术前，术后第1天及术后第7天分别进行了测定。结果：剖宫产组手术后第1天外周血CD4细胞减少，CD8细胞增多，CD4／CD8比值降低，血IgG,IgA水平明显降低，而CRP含量升高，与手术前及对照组相比较，差异具有显著性（P＜0．05）；但与术后第7天相比，无显著性差异（P＞0．05）。结论：剖宫产手术后机体出现短暂的细胞免疫与体液免疫功能降低，推测与手术创伤及麻醉等因素有关。

Effect of cesarean section on the cellular and humoral immunal function.

Objective To evaluate the effect of cesarean section on the cellular and humoral components of immune system.Methods T-lymphocyte subsets(CD 3,CD 4,CD 8,CD 4/CD 8 ratio),IgG,IgA and C-reaction protein(CRP)in peripheral blood of pregnant women were measured before and after cesarean section of 1 and 7 days respectively in operation group,and also detected in control group.Results First day after cesarean section,the peripheral blood detection showed reduced content of CD 4 lymphocytes,CD 4/CD 8 ratio,IgG and IgA,and a marked increase of the content of C-reaction protein and CD 8 lymphocytes,all of them showed significant difference compared with pre-operation and normal control(P<0^05).No difference by day 7 after operation(P>0^05).Conclusion There is transient cellular and humoral immunologic depression after cesarean section.These changes are most likely to be caused by the surgical intervention and anesthesia.