| 骨髓移植在大鼠肾移植诱导免疫耐受研究 |
| |
| 引用本文： | 曲青山,孙建军,王振璞,陈国勇,苗书斋,蔡文利,邢利.骨髓移植在大鼠肾移植诱导免疫耐受研究[J].医药论坛杂志,2009(5). |
| |
| 作者姓名： | 曲青山 孙建军 王振璞 陈国勇 苗书斋 蔡文利 邢利 |
| |
| 作者单位： | 郑州人民医院; |
| |
| 摘 要： | 目的研究在大鼠肾移植中骨髓干细胞移植对免疫耐受的诱导作用及机制。方法40只Wistar大鼠(雌雄各半)随机分为实验组和对照组,进行肾移植手术,术前经门静脉分别注射骨髓细胞及生理盐水,30天后观察肉眼和光镜下排斥反应及检测嵌合体的形成。结果实验组肉眼和光镜下排斥反应均较轻微,嵌合体检测为阳性。结论应用他克莫司并注射供体骨髓细胞,可诱导一定的免疫耐受。移植前输注供体骨髓细胞而形成的嵌合体与免疫耐受有关。
|
| 关 键 词： | 骨髓移植 他克莫司 免疫耐受 嵌合体 |
Effectiveness of Immunogical Tolerance of Kidney Transplantation in Rats by Bonemarrow Transplantation |
| |
| QU Qingshan,SUN Jianjun,WANG Zhenpu,et al Zhengzhou People's Hospital,Zhengzhou ,China.Effectiveness of Immunogical Tolerance of Kidney Transplantation in Rats by Bonemarrow Transplantation[J].Journal of Medical Forum,2009(5). |
| |
| Authors: | QU Qingshan SUN Jianjun WANG Zhenpu Zhengzhou People's Hospital Zhengzhou China |
| |
| Institution: | QU Qingshan,SUN Jianjun,WANG Zhenpu,et al Zhengzhou People's Hospital,Zhengzhou 450003,China |
| |
| Abstract: | Objective To study the protective effectiveness of immunogical tolerrance of kidney transplantation in rats by bonemarrow transplantation.Methods Forty Wistar rats were randomly assigned into the control group(n=20) and experimental group(n=20).The female animals were injected bonemarrow cell and normal salty in portal vein.After 30 days detection chimerism of blood sample and kidney's tissue regular-dye were studied.Results In experimental group positive rates of chimerism were significantly different and ... |
| |
| Keywords: | Tacrolimus Bonemarrow transplantation Immunogical tolerance Chimerism |
| 本文献已被 CNKI 等数据库收录！ |
|
