| Alzheimer病认知电位P300初步研究 |
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| 引用本文： | 朱锐明,胡纪明,赵俊雄.Alzheimer病认知电位P300初步研究[J].医学研究杂志,2005,34(6):22-23. |
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| 作者姓名： | 朱锐明 胡纪明 赵俊雄 |
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| 作者单位： | 1. 浙江省金华市第二医院精神科,321016
2. 义乌市中医医院精神科,322000 |
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| 摘 要： | 目的研究 Alzheimer 病(AD 组)与正常老人(NC 组)的认知电位 P_(300)及其亚成分。方法应用美国 Nicolet Spir-it 脑诱发电位仪和听觉 oddball 范式,记录了30例 AD 组和34例 NC 组在 Cz 和 Fz 点上 P_(300),进一步分析 P_3亚成分。结果 P_3是一个复合波,P_(3a)、P_(3b)双峰明显,清晰。在 Cz 点,AD 组 P_3双峰波出现率低于 NC 组,差异有显著性(P<0.05)。本检测结果,在 Fz 点 P_(3a)潜伏期、P_(3a)及 P_(3b)波幅和 Cz 点 P_(3a)潜伏期、P_(3a)及 P_(3b)波幅上,AD 组表现为同一趋势,即潜伏期延迟和波幅低于 NC组,有显著性差异(P<0.05或 P>0.01)。结论提示 P_(3a)和 P_(3b)是一个较好的指标,适合老年精神科临床应用。
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| 关 键 词： | Alzheimer 病 认知电位 P_(300) 亚成分 |
| 修稿时间： | 2005年2月23日 |
A Primary Study of Auditory Cognitive Potentials P300 in Alzheimer Disease |
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| Zhu Ruiming Hu Jiming Zhao Junxiong.Psychiatric.A Primary Study of Auditory Cognitive Potentials P300 in Alzheimer Disease[J].Journal of Medical Research,2005,34(6):22-23. |
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| Authors: | Zhu Ruiming Hu Jiming Zhao JunxiongPsychiatric |
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| Abstract: | Objective In order to analyze the characteristics of subcomponents of auditory cognitive potentials P_(300) of patients with Alzheimer disease(AD),the present study was made.Methods The auditory P_(300) was recorded at Cz and Fz of the scalp from 30 AD patients and normal controls(NC).The subcomponents P_(3a) and P_(3b) of P_(300) were analyzed.Results The AD group presenteda lower in cidence of P_(3a)-P_(3b),at Cz(P <0.05).Compared with the NC group,The AD group presented prolonged latencies(P_(3a),at Fz)and decreased amplitudes(P_(3a),at Fz; P_(3b),at Fz,Cz).Conclusion The subcomponent P_(3a)-P_(3b) is a reliable index of P_(300),and the further application of P_(3a)-P_(3b) is suggested. |
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| Keywords: | Alzheimer disease Cognitive potentials P_(300) Subcomponent |
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