| 2型糖尿病患者CD62P、CD63表达率测定的临床评价 |
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| 引用本文： | 黄群,杨香玖,张岩,马红.2型糖尿病患者CD62P、CD63表达率测定的临床评价[J].临床内科杂志,2001,18(3):188-189. |
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| 作者姓名： | 黄群 杨香玖 张岩 马红 |
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| 作者单位： | 福建省厦门市中山医院内分泌科 |
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| 摘 要： | 目的 探讨2型糖尿病（2型DM）患者血小板α－颗粒膜糖蛋白（CD62P）、血小板溶酶体膜糖蛋白（CD63）表达率的临床意义。方法 采用流式细胞仪，以荧光素标记单克隆抗体技术测定63例2型糖尿病患者（其中微血管病变31例，无微血管病变32例）CD62P、CD63表达率。结果 2型DM组，CD62P、CD63阳性表达率显著高于对照组（P＜0.01）。2型DM并微血管病变组显著高于无微血管病变组（P＜0.01）。结论 CD62P、CD63表达率测定对于2型DM微血管并发症的早期诊断有重要的临床意义。
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| 关 键 词： | Ⅱ型糖尿病 CD62P 血小板 α－颗粒膜糖蛋白 溶酶体膜糖蛋白 微血管病变 |
| 文章编号： | 1001-9057(2001)03-0188-02 |
| 修稿时间： | 2001年2月8日 |
Clinical evaluation of CD62p and CD63, measurement in patients with type 2 diabetes mellitus |
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| Huang Qun,Yang Xiangjiu,Zhang Yan,et al..Clinical evaluation of CD62p and CD63, measurement in patients with type 2 diabetes mellitus[J].Journal of Clinical Internal Medicine,2001,18(3):188-189. |
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| Authors: | Huang Qun Yang Xiangjiu Zhang Yan |
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| Institution: | Huang Qun,Yang Xiangjiu,Zhang Yan,et al. Department of Endocrinology,Xiamen Zhongshang Hospital,Xiamen 361004,China |
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| Abstract: | Objective To study the clinical evaluation of Platelet α-granule membrane glycoprotein(CD62P) and Platelet lysosomal granule-membrane glycoprotein(CD63) in patients with type2 diabetes mellitus.Methods The expression levels of CD62P and CD63 were measured by FCM in 63 patients with type2 diabetes mellitus (31 cases with microangiopathy,32 without microangiopathy) and in 27 controls.Results The expression levels of CD62P and CD63 in patients with type 2 diabetes mellitus was significantly higher than those in controls (P<0.01). The expression levels of CD62P and CD63 in type 2 diabetes mellitus patients with microangiopathy increased significantly in comparison with patients without microangiopathy (P<0.01).Conclusion The measurement of expression levels of CD62P and CD63 has very important clinical value in early diagnosis of type 2 diabetes mellitus with microangiopathy. |
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