非溶血性发热性输血反应的临床研究

目的：探讨ＮＨＦＴＲ的发生机制，提高临床输血疗效。方法：对１３５例未用白细胞虑器受血者进行临床观察，用标准微量淋巴细胞毒试验检测。结果：非溶血性发热性输血反应（ＮＨＦＴＲ）发生率１５．６％，血清ＨＬＡ抗体阳性率５１．８％，有反应组则达８０．８％，并提示淋巴细胞毒反应强度指数ＳＩ值〉２８％、ＨＬＡ抗体效价〉８时，反应发生率增高。结论：结合动态研究表明，ＮＨＦＴＲ与ＨＬＡ抗体直接相关。

Study on Nonhemolytic Febrile Transfusion Reactions

In order to study the mechanism of nonhemolytic febrile transfusion reactions (NHFTR), 135 patients who had received blood were observed clinically,and the HLA antibodies in serum of these patients were detected by means of the standard microlymphocytotoxictiy test (LCT). The frequence of NHFTR of these patients was 15.6% (70/135), and it was higher in patients with NHFTR (80.8%)than that in patients without NHFTR (44.4%, P<0.01). The study in dynamic observation demonastrated that NHFTR was correlated with HLA antibody. We also examined the Strength index(SI) of lymphototoxicity in 70 patients with HLA antibody positve and HLA antibody titer in 36 cases. The results showed that the frequence of NHFTR increased when SI exceedGd 28%,and HLA antibody titer exceeded 8.Therefore,the assays of SI and HLA antibody titer are important in preventing and decreasing occurence of NHFTR.