Study on abnormality and regulation of T-Lymphocyte subsets in peripheral blood of rheumatoid arthritis patients |
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Authors: | Ying-nan Li Yu-song Zhao and Xiu Li |
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Institution: | 1. Department of Rheumatoid Diseases, the Second Affiliated Hospital to Harbin Medical University, 150086, Harbin
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Abstract: | Objective To investigate the change of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T-cell subsets. Methods Thirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD3 +, CD4 + , CD8 + as well as the serum IgG and IgA levels were determined. Results The percentage of peripheral CD4 + , CD4 + /CD8 + ratio, IgG and IgA levels increased significantly (p < 0.001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD4 + /CD8 + ratio decreased obviously < 0.05). Conclusion Abnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T-lymphocyte subsets to normalize it. |
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