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骨髓造血干/祖细胞自身抗体与免疫相关性全血细胞减少
作者姓名:董 婷  李正发  欧阳红梅  沈晓梅
作者单位:1 昆明理工大学,云南省昆明市 650500 2昆明理工大学附属医院(云南省第一人民医院)血液科,云南省昆明市 650032
基金项目:云南省内设研究机构专项基金资助项目(2010NC002);云南省教育厅科学研究基金资助项目(2012J092)
摘    要:背景:免疫相关性全血细胞减少涉及多个临床学科,近年来受到高度重视。骨髓造血早期细胞自身抗体及免疫调节功能可能是其症结所在。 目的:分析骨髓造血早期(干/祖)细胞自身抗体在免疫相关性全血细胞减少症发病机制中的作用及其进展。 方法:由作者电子检索1992年3月至2012年3月PubMed、万方医学网以及CHKD数据库中关于骨髓造血细胞相关抗体的文章,中文检索词为“免疫相关性全血细胞减少症、骨髓造血细胞、自身抗体、辅助性T细胞17”,英文检索词为“Immunorelated pancytopenia,Bone marrow hematopoietic cells,Autoantibody,Th17 cells”。排除重复性研究共保留30篇进行总结分析。 结果与结论:骨髓造血细胞自身抗体是由于T淋巴细胞调控失衡,导致B淋巴细胞及其亚群数量和功能异常而产生的一类抗体。它破坏或抑制骨髓早期造血细胞成熟分化,最终引起外周血细胞减少而致病。T辅助细胞17细胞数量增多、功能亢进可能与免疫相关性全血细胞减少症患者自身抗体产生呈一定相关性,是免疫相关性全血细胞减少症发病的重要因素。

关 键 词:干细胞  干细胞学术探讨  免疫相关性全血细胞减少症  骨髓造血干/祖细胞  骨髓造血细胞  T辅助细胞17  自身抗体  白细胞介素17  T淋巴细胞调控  IgG  IgM  流式细胞术双标法  省级基金  
收稿时间:2012-09-21

Autoantibodies on bone marrow hematopoietic stem/progenitor cells and immunorelated pancytopenia
Authors:Dong Ting  Li Zheng-fa  Ouyang Hong-mei  Shen Xiao-mei
Institution:1 Kunming University of Science and Technology, Kunming  650500, Yunnan Province, China 
2 Department of Hematology, First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming  650032, Yunnan Province, China
Abstract:BACKGROUND:mmunorelated pancytopenia involves in multiple clinical disciplines and has been paid more and more attention in recent years. Autoantibodies on bone marrow hematopoietic stem cells and immune regulation function may be the crux of the problem. OBJECTIVE:To study the progress on the role of bone marrow hematopoietic stem cell-associated antibodies in the pathogenesis of immunorelated pancytopenia. METHODS: A computer retrieval of PubMed, WangFang Med Online and CHKD database was conducted for articles regarding the autoantibodies on bone marrow hematopoietic stem cells published from March 1992 to March 2012. The keywords were “immunorelated pancytopenia, bone marrow hematopoietic cells, autoantibody, T helper 17 cells”. Repetitive articles were excluded, and finally 30 articles were included in result analysis. RESULTS AND CONCLUSION: The production of autoantibodies on bone marrow hematopoietic cells is due to the imbalance in T lymphocyte regulation resulting in abnormal quantity and function of B lymphocyte and its subset. They destroyed or inhibited the differentiation and maturation of bone marrow hematopoietic cells, leading to a reduction of peripheral blood cells eventually. The increasing number of T helper 17 cells and the hyperfunction of T helper 17 cells may be associated with the production of autoantibodies in patients with immunorelated pancytopenia, which is an important factor for the pathogenesis of immunorelated pancytopenia.
Keywords:stem cells  stem cell academic discussion  immunorelated pancytopenia  bone marrow hematopoietic stem/progenitor cells  bone marrow hematopoietic cells  T helper 17 cells  autoantibodies  interleukin-17  T lymphocyte regulation  IgG  IgM  double-labeling flow cytometry  provincial grants-supported paper  
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