种植体周围龈沟液高迁移率族蛋白B1的水平

背景：近来研究发现高迁移率族蛋白B1在各种炎症中作为一种重要的炎症因子发挥了明显作用。目的：测定种植体周围黏膜炎患者龈沟液中高迁移率族蛋白B1的水平,探讨高速泳动族蛋白B1与种植体周围黏膜炎的关系。方法：选择健康种植体(n=39)、轻度种植体周围黏膜炎(n=24)和中度种植体周围黏膜炎(n=16)患者,测定种植体周围龈沟液量、龈沟液中高速泳动族蛋白B1总量及浓度;同时检测种植体周围黏膜炎的牙龈指数、菌斑指数、探诊深度和松动度。结果与结论：轻度种植体周围黏膜炎组龈沟液量、高迁移率族蛋白B1总量和浓度高于健康种植体组(P < 0.01),但低于中度种植体周围黏膜炎组(P < 0.01)。牙龈指数与龈沟液量之间存在正相关关系(P < 0.01),牙龈指数、菌斑指数与高迁移率族蛋白B1总量及浓度存在正相关关系(P < 0.01),探诊深度、松动度与高迁移率族蛋白B1浓度及总量间无明显相关性(P > 0.05)。表明种植体周围龈沟液量及龈沟液中高迁移率族蛋白B1水平与种植体周围黏膜炎的病变程度有关,检测龈沟液中高速泳动族蛋白B1水平可作为临床诊断种植体周围黏膜炎的客观指标。

High mobility group box 1 protein level in peri-implant crevicular fluid

BACKGROUND:Recent studies have found that high mobility group box 1 protein (HMGB-1) as an important inflammatory factor plays a significant role in various inflammations.OBJECTIVE:To determine the HMGB-1 level in the peri-implant gingival crevicular fluid and to investiage the correlation of HMGB-1 and peri-implant mucositis.METHODS:Patients with healthy implant (n=39), with mild peri-implant mucositis (n=24) and moderate peri-implant mucositis (n=16) were enrolled. The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were detected. Clinical parameters were measured to investigate their relationships, including gingival index, mobility, plaque index, probing depth.RESULTS AND CONCLUSION:The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were significantly higher in the patients with mild peri-implant mucositis than in the healthy implant patients (P < 0.01), but lower than the moderate peri-implant mucositis patients (P < 0.01). Gingival crevicular fluid volume was positively correlated with gingival index and plaque index (P < 0.01). The total amount of HMGB-1 was positively correlated with gingival index and probing depth (P < 0.01). No significant difference was found between probing depth and mobility and the level and total amount of HMGB-1. This investigation show that HMGB-1 level in the gingival crevicular fluid may be as a diagnostic marker for peri-implant mucositis.