婴幼儿罗叶泵聚氨酯瓣膜的制作及功能测试 |
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作者姓名: | 吴岳恒 黄焕雷 范瑞新 祁周措 姚丽明 武长礼 陆平兰 成安衡 肖学钧 |
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作者单位: | 广东省医学科学院,广东省人民医院,广东省心血管病研究所,1医学研究中心,2心外科,广东省广州市 510100 |
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基金项目: | 国家自然科学基金资助(30901468);广东省教育部产学研结合项目基金资助(2008B090500210)。 |
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摘 要: | 背景:现有成人罗叶泵使用机械瓣,但机械瓣膜的尺寸较大,对血液破坏较大,不适于婴幼儿心室辅助泵,故设计和制作尺寸小、血栓形成低的高分子瓣膜是目前研究的热点。
目的:设计和制作20 mL婴幼儿罗叶泵的瓣膜,并进行基本功能测试和疲劳测试
方法:通过MASTERCAM软件设计瓣膜尺寸和形状,通过制作瓣膜模具和注塑获得聚氨酯瓣膜;根据ISO5840的要求测试聚氨酯瓣膜的静止泄露、跨瓣压差和耐疲劳性能。
结果与结论:制作了聚氨酯三叶瓣膜,但注塑失败率较高;所制作的三叶瓣膜的基本功能基本符合ISO 5840的要求;聚氨酯瓣膜在连续运行1.0×107次后,20 mL罗叶泵的搏出量的变化率为5.2%。两个聚氨酯瓣膜保持完整,瓣叶无变化。说明设计并成功制作了聚氨酯三叶瓣膜;所制备的聚氨酯瓣膜能满足20 mL罗叶泵的需要,已具备了临床试验的能力。
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关 键 词: | 器官移植 心肺移植 心室辅助装置 罗叶泵 聚氨酯 三叶瓣膜 耐疲劳 心脏装置 国家自然科学基金 |
收稿时间: | 2012-11-10 |
Production and functional testing of polyurethane valve of the pediatric Luo-Ye pump |
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Authors: | Wu Yue-heng Huang Huan-lei Fan Rui-xin Qi Zhou-cuo Yao Li-ming Wu Chang-li Lu Ping-lan Cheng An-heng Xiao Xue-jun |
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Institution: | 1Medical Research Center, 2Department of Cardiovascular Surgery, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou 510100, Guangdong Province, China |
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Abstract: | BACKGROUND: The mechanical valves used in the adult Luo-Ye pump have a large size and great destruction to blood, which are not suitable for infant ventricular assist pump. Therefore, designing and producing a high molecular valve with small size and low incidence of thrombosis is a research hotspot.
OBJECTIVE:To design and produce a valve of 20 mL infant Luo-Ye pump, and to test its basic functions and fatigue properties.
METHODS: The size and shape of valve was designed with MASTERCAM software, polyurethane valve was obtained through producing the valve model and plastic injection; the static leakage, pressure drop and fatigue resistance of polyurethane valve were tested according to the ISO5840 requirements.
RESULTS AND CONCLUSION:The polyurethane trefoil valve was produced, but the failure rate of plastic injection was high; the basic function of the trefoil valve met the ISO5840 requirements bascially; after continuously operated 1.0×107 times, stroke volume of 20 mL Luo-Ye pump was changed 5.2%, and two polyurethane valves and valve leaflets did not change and damage. Polyurethane trefoil valve was designed and produced successfully; polyurethane valves could meet the needs of 20 mL Luo-Ye pump, which already have the ability to clinical trials. |
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Keywords: | organ transplantation heart-lung transplantation ventricular assist device Luo-Ye pump polyurethane trefoil valve fatigue resistance cardiac device National Natural Science Foundation of China |
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