| 急性脊髓损伤后的氧化应激及其抗氧化治疗 |
| |
| 作者姓名： | 张思 王烁宇 李华南 张国福 顾兵 |
| |
| 作者单位： | 1. 江西科技师范大学生命科学学院，南昌，330013,中国
2. 江西中医药大学药学院，南昌,330006,中国
3. 江西中医药大学附属医院脊柱外科，南昌，330006，中国 |
| |
| 基金项目： | 国家自然科学基金资助项目（No.30960448），江西省自然科学基金项目（No.20114BAB205033），江西省教育厅科技项目（No.GJJ11596） |
| |
| 摘 要： | 急性脊髓损伤可导致严重的运动、感觉功能障碍。由自由基引起的氧化应激在继发性损伤的病理生理过程中占有重要地位。通过有效的抗氧化干预抑制损伤后生物大分子的过氧化反应，将成为药物治疗脊髓损伤的一条策略。本文主要介绍氧化应激的产生原因、作用过程和参与急性脊髓损伤的病理生理机制，并综述抗氧化药物实验研究最新进展，旨在为寻找安全有效的药物提供参考依据。
|
| 关 键 词： | 脊髓损伤 氧化应激 抗氧化 |
Oxidative Stress and Antioxidant Therapy after Acute Spinal Cord Injury |
| |
| Authors: | ZHANG Si WANG Shuo-yu LI Hua-nan ZHANG Guo-fu GU Bing |
| |
| Institution: |
1. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang, 330013, China
2. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China
3. Department of Spine Surgery, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China |
| |
| Abstract: | Acute spinal cord injury can lead to severe motor and sensory dysfunction. Oxidative stress caused by free radical plays an important role in the pathophysiology of secondary injury. Inhibition of biological macromolecules peroxidation damage through antioxidant intervention may be an effective strategy for drug therapy of spinal cord injury. This paper mainly introduces the cause, process and participation of oxidative stress in the pathophysiological mechanism of acute spinal cord injury, and also reviews the recent advances in antioxidant drug research, aiming to facilitate the discovery of safe and effective antioxidant drugs for potential treatment of acute spinal cord injury. |
| |
| Keywords: | spinal cord injury oxidative stress antioxidant |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|
