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血管成形与脐带干细胞移植治疗糖尿病足:3个月血管造影评价
引用本文:秦汉林,贺克武,高 斌,季亚莉,黄永翠,王胜琴,胡国平,周学勇. 血管成形与脐带干细胞移植治疗糖尿病足:3个月血管造影评价[J]. 中国组织工程研究, 2013, 17(14): 2544-2551. DOI: 10.3969/j.issn.2095-4344.2013.14.011
作者姓名:秦汉林  贺克武  高 斌  季亚莉  黄永翠  王胜琴  胡国平  周学勇
作者单位:1合肥市第一人民医院介入科,安徽省合肥市 2360012安徽省血液中心,安徽省合肥市 236001
基金项目:安徽省科技厅年度计划项目(09020303043)。
摘    要:背景:目前对糖尿病继发肢体动脉闭塞尚无有效的药物治疗,最终多导致截肢,预后很差。目的:以血管成形联合人脐带间充质干细胞移植治疗糖尿病足,3个月后行血管造影评价效果。方法:确诊症状严重伴有下肢动脉不同程度病变的Fontain Ⅳ期糖尿病足40例52条患肢,对照组12例患者18条患肢给予单纯介入治疗,实验组28例34条患肢给予介入联合人脐带间充质干细胞经导管灌注及溃疡周围注射治疗,随访3个月。结果与结论:治疗后患肢冷感、疼痛、麻木等临床症状持续改善,患肢皮温、踝肱指数值及跛行距离均增加。治疗3个月后复查造影,新生血管增多,溃疡逐渐愈合或缩小,输注前后未出现严重并发症和不良反应。说明采用血管成形联合人脐带间充质干细胞移植治疗糖尿病足,方法可行、安全,近期疗效满意。

关 键 词:干细胞  干细胞移植  2型糖尿病  外周血管病变  糖尿病足  溃疡  介入  血管成形  人脐带间充质干细胞  移植  疗效  并发症  省级基金  干细胞图片文章  
收稿时间:2012-10-25

Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation
Qin Han-lin,He Ke-wu,Gao Bin,Ji Ya-li,Huang Yong-cui,Wang Sheng-qin,Hu Guo-ping,Zhou Xue-yong. Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(14): 2544-2551. DOI: 10.3969/j.issn.2095-4344.2013.14.011
Authors:Qin Han-lin  He Ke-wu  Gao Bin  Ji Ya-li  Huang Yong-cui  Wang Sheng-qin  Hu Guo-ping  Zhou Xue-yong
Affiliation:1 Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei  230061, Anhui Province, China
2 Blood Center of Anhui Province, Hefei  236001, Anhui Province, China
Abstract:BACKGROUND:At present, there is no effective drug for the treatment of diabetic arteniosclerosis obliterons, and most of the patients have to receive amputation, and have poor prognosis.OBJECTIVE:To treat the diabetic foot with human umbilical cord mesenchymal stem cells transplantation combined with angioplasty, and to perform the angiographic evaluation at 3 months after operation. METHODS:Forty cases (52 limbs) diagnosed with severe symptoms of Fontain Ⅳ diabetic foot accompanied with varying degrees of lower extremity arterial disease were included. The 12 cases (18 limbs) in the control group received simple interventional treatment, and 28 cases (34 limbs) in the experimental group were given human umbilical cord mesenchymal stem cells endovascular infusion and injection around the ulcer. Then all the patients were followed-up for 3 months.   RESULTS AND CONCLUSION:Local cool-feeling, pain and numbness after treatment were improved continuously in a certain extent; skin temperature, ankle-brachial pressure index and claudication distance were improved persistently. Re-examination angiography at 3 months after treatment showed that the neovessels were increased significantly and the ulcer was healed or decreased gradually. No serious complications and adverse reactions were observed before and after infusion. The results indicate that human umbilical cord mesenchymal stem cell transplantation combined with angioplasty is a safe, effective and satisfactory method for severe diabetic foot.
Keywords:stem cells   stem cell transplantation   type 2 diabetes   peripheral vascular disease   diabetic foot   ulcer   intervention   angioplasty   human umbilical cord mesenchymal stem cells   transplantation   efficacy   complications   provincial grants-supported paper   stem cell photographs-containing paper  
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