牙髓牙本质组织工程生物支架材料的研究进展

背景：组织工程方法中选择合适的支架是关键性的步骤。目的：回顾分析牙髓牙本质组织工程中支架材料的应用研究。方法：由第一作者检索1993至2012年 PubMed数据及万方数据库有关牙髓牙本质组织工程中支架材料应用研究等方面的文献。结果与结论：在牙髓牙本质组织工程中有包括天然生物、人工合成材料和复合材料在内的大量生物材料可供选择,每一种材料都有各自的生物学特点。其中胶原、聚酯、羟基磷灰石等是研究较多的支架材料。自组装多肽水凝胶是由氨基酸制成的新型支架材料,满足理想牙髓牙本质组织工程支架材料的大部分要求,是一种前景广阔的牙髓牙本质组织工程支架材料。

Biological scaffolds for pulp-dentin tissue engineering

BACKGROUND:For tissue engineering strategies, the choice of an appropriate scaffold is a crucial step.OBJECTIVE:To retrospectively analyze the application of scaffold materials in pulp-dentin tissue engineering.METHODS:The first author searched PubMed and Wanfang databases (1993/2012) for relevant articles about scaffold materials used in pulp-dentin tissue engineering.RESULTS AND CONCLUSION:A vast variety of biomaterials including natural materials, synthetic materials, and composite materials are available in pulp-dentin tissue engineering. Each material has its unique biological properties. Among them, collagen, polyester and hydroxyapatite scaffolds have been greatly studied. Self-assembling peptide hydrogel made from amino acid is a new-type scaffold that meets most of the demands of an ideal pulp-dentin tissue engineering scaffold. Therefore, self-assembling peptide hydrogel is a promising pulp-dentin tissue engineering scaffold.