二氧化钛纳米管的理论研究进展及临床实践

背景：二氧化钛纳米管阵列电化学阳极氧化钛是目前应用前景较好的纳米材料之一。目的：综述二氧化钛纳米管在临床应用方面的研究进展。方法：以TiO₂ nanotubes，Anodization，biomaterials为检索词，检索PubMed 数据库2000年1月至2013年6月中有关二氧化钛纳米管临床应用领域研究的文献。排除重复研究及陈旧研究，共保留47篇文献进行综述。结果与结论：从检索到的47篇文献进行总结分析发现，二氧化钛纳米管能够促进包括人成骨细胞，间充质干细胞的黏附和增殖。体内实验证实，二氧化钛纳米管能够促进钛金属内植物在体内的骨整合。此外，二氧化钛纳米管还可作为载体负载其他药物如生长因子和抗生素以促进材料生物形容性及预防细菌黏附。结果说明，二氧化钛纳米管可促进材料的体内骨整合，具有良好的生物相容性。

Research progress and clinical practice of TiO2 nanotubes

BACKGROUND:TiO2 nanotube array prepared by anodic oxidation is a nanomaterial having a perfect promising application at present. OBJECTIVE:To review the research progress of TiO₂ nanotube in clinic. METHODS: The key words were TiO₂ nanotubes, anodization, and biomaterials. We retrieved PubMed Database for articles concerning the clinical application of TiO2 nanotube published from January 2000 to June 2013. Repetitive and old studies were excluded, and 47 literatures were included for the review. RESULTS AND CONCLUSION:The summarized results of the 47 literatures showed that TiO2 nanotube promoted the adhesion and proliferation of osteoblasts and mesenchymal stem cells including human. In vivo experiments verified that TiO₂ nanotube could be used as a carrier to carry other drugs such as growth factor and antibiotics so as to promote the biocompatibility of the materials and to prevent bacterial adhesion. Results suggested that TiO₂ nanotube contributed to the osseointegration of the material in vivo, and had a good biocompatibility.