聚乙烯醇/壳聚糖载药电纺纤维膜的制备及性能表征

目的：使用静电纺丝技术制备载不同含量丹参素钠的聚乙烯醇/壳聚糖载药电纺纤维膜。 方法：以聚乙烯醇(PVA)和壳聚糖(CS)为载体，丹参素钠(SAS)为模型药物，制备载药电纺纤维膜；借助扫描电镜观察纤维形貌，利用红外光谱分析其成分，用紫外可见吸收光谱仪检测纤维膜含药量，绘制药物释放曲线。 结果：不同含量丹参素钠的聚乙烯醇/壳聚糖载药电纺纤维膜纤维直径均在280~390 nm 之间，纤维膜含药量高，并能较好地实现丹参素钠的缓控释放。 结论：研究制备成功的聚乙烯醇/壳聚糖载药电纺纤维膜制备工艺简单，载药均匀，有明显的缓释性，可为皮肤局部给药系统的研究提供新策略。

Preparation and performance characterization of electrospun drug loaded poly (vinyl alcohol)/chitosan nanofibrous membrane

Objective： To prepare nanofibrous membranes of poly (vinyl alcohol)/chitosan (PVA/CS) loaded with varied salvianic acid A sodium (SAS) contents. Methods： Ultrafine fiber mats were prepared with PVA/CS as matrix and SAS as model drug.The structure and morphology of the nanofibrous membranes were characterized by FT-IR and SEM.Drug-loading amount and drug release profiles of these membranes were determined by UV VIS spectra，and the degradation of the membranes was also investigated. Results： Average diameters of PVA/CS/SAS nanofibers with different SAS contents were 280~390 nm.Drug-loading amount of these nanofibrous membranes was high and exhibited sustained and controlled release behavior for SAS. Conclusion： The PVA/CS/SAS nanofibrous membrane prepared in this study loads drug uniformly and has remarkably sustained release behavior，which may offer strategies for the research and development of novel topical drug delivery systems.