自体外周血干细胞移植治疗周围神经损伤

背景：关于神经干细胞对周围神经损伤的治疗已有多篇报道,但外周血干细胞对周围神经损伤治疗鲜有报道。 目的：探讨自体外周血干细胞移植治疗周围神经损伤使失神经骨骼肌重获神经再支配的临床应用。 方法：应用外周血干细胞治疗周围神经损伤6例,同时与周围神经损伤单纯行神经断端吻合或神经移植10例比较。2组患者术后常规肌注鼠神经生长因子一两个疗程,同时给予针灸、理疗、经皮电刺激治疗及功能康复训练。 结果与结论：两组患者随访均超过6个月。干细胞移植组运动神经传导速度和感觉神经传导速度的恢复率要明显高于单纯神经吻合组。提示周围神经损伤后给予修复局部用外周血干细胞移植能够使远端失神经骨骼肌早期重新获得神经再支配。

Autologous peripheral blood stem cell transplantation for treatment of peripheral nerve injury

BACKGROUND:Neural stem cells for treatment of peripheral nerve injury have been much reported. But few studies are reported regarding peripheral blood stem cells for treatment of peripheral nerve injury. OBJECTIVE:To investigate the clinical application of autologous peripheral blood stem cells transplantation reinnervating denervated skeletal muscle in the treatment of peripheral nerve injury. METHODS:Six patients received peripheral blood stem cells transplantation for treatment of peripheral nerve injury. At the same time, 10 controls received only anastomosis or nerve transplantation. All patients were intramuscularly administered mouse nerve growth factors one or two treatment courses. In addition, acupuncture, physical therapy, transcutaneous electrical stimulation and functional rehabilitation were also given.  RESULTS AND CONCLUSION:Two groups of patients were followed up over 6 months. The motor nerve and sensory nerve recovered better in patients who received peripheral blood stem cells transplantation than in patients who underwent simple neural anastomosis. These findings suggest that peripheral blood stem cells transplantation can reinnervate the distal denervated skeletal muscle after peripheral nerve injury.