血红素氧化酶1对移植肝脏缺血再灌注损伤的保护

背景：在肝移植过程中,肝脏的缺血再灌注损伤导致的移植肝原发性无功能一直困扰着广大移植专家学者。血红素氧化酶1参与多种疾病及病理过程,通过抗氧化、抗炎、抗凋亡等多种机制发挥组织器官保护作用。目的：对血红素氧化酶1对移植肝缺血再灌注损伤的保护作用进行综述。方法：由第一作者应用计算机检索PubMed数据库1992年1月至2009年12月及中国期刊网全文数据库2003年1月至2010年12月有关血红素氧化酶1对移植肝缺血再灌注损伤保护作用的文章,英文检索词为“heme oxygenase-1,ischemia-reperfusion injury,liver graft”,中文检索词为“血红素氧化酶1,移植肝,缺血再灌注损伤”。排除研究目的与课题无关及内容重复的研究,共保留34篇文献进行综述。结果与结论：血红素氧化酶1可能是哺乳动物体内分布最广、保护作用最重要的基因。血红素氧化酶1及其催化产物组成了机体重要的内源性保护系统,参与多种疾病及病理过程,通过抗氧化、抗炎、抗凋亡等多种机制发挥组织器官保护作用,具有重要的临床应用潜能。血红素氧化酶1对移植肝的缺血再灌注损伤具有明显的保护作用,如何通过转基因手段将其应用于临床,保护移植肝减轻缺血再灌注损伤,提高移植肝成活率,有着广阔的临床应用前景,也是未来所要研究的方向。

Heme oxygenase-1 protects against ischemia-reperfusion injury following liver transplantation

BACKGROUND:During liver transplantation, liver ischemia-reperfusion injury induced primary poor liver graft function has been puzzled the majority of transplant experts and scholars. Heme oxygenase-1 is involved in a variety of diseases and pathological processes, and can protect the tissue and organ through its antioxidant, anti-inflammatory, anti-apoptotic and other mechanisms.OBJECTIVE:To review the protective effect of heme oxygenase-1 against ischemia-reperfusion injury in liver graft.METHODS:A computer-based search of PubMed database 1992-01/2009-12 and China Journal Full-Text database 2003-01/2010-12 was performed by the first author for the articles on the protective effect of heme oxygenase-1 on ischemia-reperfusion injury in liver graft. The key words were “heme oxygenase-1, ischemia-reperfusion injury, liver graft” in English and Chinese. The repetitive research and Meta-analysis were excluded, and totally retained 34 articles for review.RESULTS AND CONCLUSION:Heme oxygenase-1 may be the most widely distributed gene in animal body, and it had the most important protective effect. Heme oxygenase-1 and its catalytic product compose an important endogenous protection system that is involved in a variety of diseases and pathological processes, and protects the tissue and organ through its antioxidant, anti-inflammatory, anti-apoptotic and other mechanisms with an important clinical application potential. Heme oxygenase-1 has a significant protective effect on ischemia-reperfusion injury in liver graft. Heme oxygenase-1 has a broad clinical application prospect in reducing the ischemia-reperfusion injury and improving the liver graft survival rate if we know how to apply it in clinic by means of transgene, and that is the research direction in future.