梯形面积法研究蛇床子素在大鼠体内组织分布

目的：研究蛇床子素在大鼠体内的组织分布特征，为临床合理用药提供合理依据。方法：大鼠腹腔注射30，120 mg·kg^-1蛇床子素后，采用RP-HPLC法测定大鼠组织中不同时间点的药物浓度，分析蛇床子素在大鼠体内的组织分布特点。结果：大鼠ip蛇床子素后，组织分布较快，给药5 min均可检测到蛇床子素，10 min内心、肝、肺、肾均可达到峰值。当给药浓度增加4倍时,蛇床子素在各组织中的达峰时间没有显著性变化，只是相应时间点的药物浓度均略有升高,药物消除的时间也相应延长。结论：蛇床子素在大鼠组织中分布快广泛，消除也快，且可能穿越血脑屏障和血睾屏障。

Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

Objective: To study the tissue distribution of ostholon rats and to provide bases for clinical applications. Methods: After osthol was administered to rats (30, 120 mg·kg^-1 ;ip), the concentration of osthol in rat tissues after different time was determined by RP-HPLC. Results: Osthol distributed rapidly in the tissues after ip: eight tissues can detect osthol after 5 min. Heart, liver, lung and kidney all reached C_max in 10 min_. When the dose is increased 4 folds, T_peaks of osthol in tissues had no significant changes, except the concentration and elimination time increased slightly corresponding to the same time-point. Conclusion: Osthol was distributed rapidly and extensively in the rat’s body and may pass through blood-brain-barrier and blood-testis-barrier.