Role of chronic obstructive pulmonary disease in lung cancer pathogenesis |
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Authors: | Clara E Green Alice M Turner |
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Institution: | Clara E Green, Alice M Turner, Centre for Translational Inflammation Research, University of Birmingham, B152WB Birmingham, United KingdomAlice M Turner, Heart of England NHS Foundation Trust, B9 5SS Birmingham, United Kingdom |
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Abstract: | Chronic obstructive pulmonary disease (COPD) and lung cancer are two important smoking related conditions. However, COPD has been shown to be an independent risk factor for lung cancer regardless of smoking history, suggesting that COPD and lung cancer may share a common pathogenesis. This review summarizes the epidemiology of lung cancer and COPD briefly, as well as discussing the potential for shared genetic risk, and shared genomic mechanisms, such as epigenetic changes or DNA damage induced by smoking. How key areas of COPD pathogenesis, such as inflammation, oxidative stress and protease imbalance may contribute to subsequent development of cancer will also be covered. Finally the possibility that consequences of COPD, such as hypoxia, influence carcinogenesis will be reviewed. By understanding the pathogenesis of COPD and lung cancer in detail it is possible that new treatments may be developed and the risk of lung cancer in COPD may be reduced. |
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Keywords: | Chronic obstructive pulmonary disease Non-small cell lung carcinoma Smoking Oxidative stress Inflammation |
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