| 神经干细胞的命运决定机制及其靶点调控的研究进展 |
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| 作者姓名： | 马寅仲 陈乃宏 |
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| 作者单位： | 1.天然药物活性物质与功能国家重点实验室，新药作用机制研究与药效评价北京市重点实验室,中国医学科学院药物研究所，北京，100050，中国
2.天津中医药大学，天津，300193，中国 |
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| 基金项目： | 国家863计划基金（No.2012AA020303），长江学者和创新团队发展计划(PCSIRT No.IRT1007)，国家自然科学基金（No.81274122、No.81173578），国家国际科技合作项目(No.2010DFB32900)，创新药物研究开发技术平台建设（No.2012ZX09301002-004、No.2012ZX09103101-006），教育部博士点基金重点项目(No.20121106130001)，北京市自然基金重点项目(No.7131013) |
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| 摘 要： | 神经干细胞（neural stem cells, NSCs）是哺乳动物神经系统中神经元、星型胶质细胞、少突胶质细胞的分化来源。近年来对于NSCs的增殖与分化机制及其在临床治疗神经退行性疾病的研究在世界范围内引起了学者们的极大兴趣。多种细胞调节因子存在于微环境中共同调节NSCs的自我更新、迁移及分化。其中Notch通路，NF-κB通路与Wnt通路尤其作为NSCs发育中的“命运决定者”而受到广泛的关注。它们中的每条通路均具有独自控制分化与增殖的能力。本文针对Notch通路、Wnt通路以及NF-κB通路对NSCs增殖与分化的作用机制进行了归纳与阐述，对其中潜在的药物作用靶点与目前最新的内、外源化合物对NSCs增殖与分化的作用进行了总结，希望对今后神经再生方面的研究提供理论指导。
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Research Advances on Fate Decision of NSCs and Its Potential Target Modulation |
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| Authors: | MA Yin-zhong CHEN Nai-hong |
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| Institution: | 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
2. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China |
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| Abstract: | Neural stem cells (NSCs) are the source of neurons, oligodendrocytes and astrocytes in mammal neural system. In recent years, study base on the mechanisms of NSCs differentiation，proliferation and clinic research on neural degeneration diseases have been held great interests. Multiple cell regulation factors in the microenvironment co-regulate the self-renewal, differentiation and migration of NSCs. Among the factors, Notch，NF-κB and Wnt have been called “fate decision makers” and gained extensive attention. Each of them can control either differentiation or proliferation on their own. Here we reviewed the mechanisms of fate decision of three major signaling pathways: Notch, Wnt and NF-kB and summarized the potential drug targets and exogenous regulation factors, hoping to provide some guidance for future stem cell research. |
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| Keywords: | neural stem cell fate decision notch wnt NF-kB |
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