成人GHD患者的血清瘦素、脂联素、内脂素水平及相关性研究

目的 了解成人生长激素缺乏症(GHD)患者体内的瘦素(leptin)、脂联素(ADP)、内脂素(visfatin)水平变化以及与体质指标、血脂及各种激素指标的关系。 方法 纳入成人GHD患者40例(男19例)作为观察组,健康人36例(男18例)作为正常对照组。收集两组的基本资料,包括身高、体质量、腰围、臀围、血脂、甲状腺激素、生长激素、胰岛素、性激素等指标。采集空腹静脉血标本进行血清瘦素、脂联素、内脂素水平测定。 结果 GHD组腰臀比、胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、瘦素、脂联素、内脂素水平均高于正常对照组(P<0.05);GHD组生长激素(GH)、胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)、硫酸脱氢表雄酮(DHEA-S)水平均低于正常对照组(P<0.05)。②经多因素logistic回归分析得出,内脂素水平升高的人群患成人GHD的风险增高(OR=1.430,P<0.05)。 结论 内脂素水平升高的人群患GHD的风险较正常人群增高。

Serum Leptin,Adiponectin, Visfatin Levels in Adult GHD Patients and Correlation Studies

Objective To investigate the change of leptin, adiponectin and visfatin levels in adult growth hormone deficiency (GHD) patients, and its relationship with other indicators. Methods 40 adult GHD patients (19 males) entered the observation group with 36 cases of healthy individuals (18 males) as the control group. Basic information (height, body mass, waistline, hipline etc.) was collected from both groups. Fasting venous blood samples were collected to measure the leptin, adiponectin and visfatin levels. Results The GHD group had a higher waist to hip ratio, and higher levels of cholesterol, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), leptin, adiponectin and visfatin, but lower levels of growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and dehydroepiandrosterone sulfate (DHEA-S) when campared with that of the control group (P<0.05). Logistic regression analysis demonstrated that adult GHD patients are associated with elevated levels of visfatin (OR=1.430, P<0.05). Conclusion Our study implied that adult GHD patients are associated with elevated levels of visfatin.