三种材料缝合气管吻合口愈合中的生物力学特征与气管重塑

背景：研究表明气管及支气管吻合材料的选用对吻合口愈合质量可产生不同影响。 目的：以3种缝合材料建立兔气管重建模型,分析气管吻合口愈合过程中生物力学特征与气管重塑的关系。 方法：将18只新西兰大白兔随机分为3组,分别以丝线、涤纶线和人工合成可吸收缝线建立气管重建模型。 结果与结论：①吻合口处气管抗拉强度：术后2周,3组气管在一定外力下于接近吻合口处断裂,缝线本身并未断裂;术后4,8周,吻合气管在远离吻合口部位破裂,均未从吻合口处断裂。②吻合口处气管顶破强度：术后2,4,8周,3组均在气管膜部破裂。③吻合口Ⅰ型胶原蛋白水平：术后2周涤纶线组低于较其他两组(P < 0.05),术后4,8周3组间差异无显著性意义。表明不论使用何种缝线均不影响气管吻合口的稳定性,但不同缝线在不同时期引起的气管狭窄有一定差别。

Biomechanical property and tracheal remodeling during tracheal anastomotic healing after tracheal suture with three different materials

BACKGROUND:Researches have showed that the selection of trachea and bronchi anastomotic materials has different effects in the healing quality. OBJECTIVE:To establish the rabbit tracheal reconstruction model with three different suture materials and to detect the relationship between biomechanical property and tracheal remodeling during the different phases of the rabbit wound healing. METHODS:Eighteen New Zealand white rabbits were divided into three groups randomly, and the silk thread, dacron thread and synthetic absorption suture were used to establish tracheal reconstruction model. RESULTS AND CONCLUSION:Tensile strength of anastomosis trachea: The tracheas anastomosed by three sutures were fractured close to the anastomotie stoma under external forces after 2 weeks; otherwise, the sutures were not torn. After 4 and 8 weeks, the tracheas were fractured in the part far away from anastomotie stoma, and no trachea was fractured on the anastomotie stoma. Bursting strength of anastomosis trachea: After 2, 4 and 8 weeks, three anastomotie stomas were burst from tracheal membranous. Collagen Ⅰ concentration: the collagen Ⅰconcentration in dacron thread group was lower than that in the other two groups (P < 0.05). There was no significant difference of collagen Ⅰ concentration after 4 and 8 weeks among three groups. It shows that the stability of the tracheal anastomosis will not be influenced by the suture material, but tracheal stenosis has certain differences after suture with different suture materials at various periods.