运动性过氧化物酶体增殖物受体γ共激活因子1α的变化机制

背景：研究发现,过氧化物酶体增殖物受体γ共激活因子1α可能在运动诱导骨骼肌的适应机制起着重要的作用,参与调节运动诱导多种生物学反应过程。 目的：综述过氧化物酶体增殖物受体γ共激活因子1α与运动性骨骼肌的适应机制相关方面的研究。 方法：以PGC1α,skeletal muscle,exercise,mitochondrial biogenesis,adaptations为检索词,检索Pubmed数据库(1995年1月至2010年10月)。文献检索语种限制为英文。纳入过氧化物酶体增殖物受体γ共激活因子1α与运动性骨骼肌适应的相关的内容,排除重复性研究。计算机初检得到59篇文献,根据纳入排除标准,对37篇进行分析。 结果与结论：耐力训练可增加骨骼肌膜的转运蛋白的表达、线粒体代谢酶的活性和毛细血管的密度等,从而增加骨骼肌氧化能力,提高碳水化合物和脂肪酸的氧化能力。氧化物酶体增殖物受体γ共激活因子1α基因敲除或过表达转基因小鼠研究表明在维持骨骼肌线粒体代谢和抗氧化酶表达,氧化物酶体增殖物受体γ共激活因子1α起着重要的作用。氧化物酶体增殖物受体γ共激活因子1α影响运动性线粒体蛋白的适应。但是,氧化物酶体增殖物受体γ共激活因子1α不是惟一的因素,其他的一些因素同样涉及到基础的表达和运动性骨骼肌的适应机制。运动诱导氧化物酶体增殖物受体γ共激活因子1α表达和活性的提高可能是运动性线粒体的适应一个机制,合理体力活动可获得健康的效果。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：

Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and exercise-induced skeletal muscle adaptations

BACKGROUND: Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) may play     an important role in the exercise-induced skeletal muscle adaptation, which is involved in the regulation of a   variety of exercise-induced biological reactions. OBJECTIVE: To review the PGC-1α and endurance training induced skeletal muscle adaptations. METHODS: The relevant articles about relationship between PGC-1α and endurance training-induced skeletal muscle adaptations were searched from PubMed database (1995-01/2010-10) by using the keywords of “PGC-1α, skeletal muscle, exercise, mitochondrial biogenesis, adaptations”, and the language was limited to English. Repetitive contents were deleted. The 59 collected articles were searched. According to the criterion, 37 were classified and sorted. RESULTS AND CONCLUSION:Endurance training can typically increase the expression/activity of membrane transporters and mitochondrial metabolic enzymes as well as increase capillarisation in the skeletal muscle, together enhancing the oxidative capacity of the muscle and the ability to oxidize both carbohydrates and fatty acids. Studies in PGC-1α knockout and overexpression mice have clearly demonstrated that PGC-1α plays an important role in maintaining the expression of mitochondrial metabolic and anti-oxidant enzymes in the skeletal muscle and does influence exercise-induced adaptations of mitochondrial proteins. However, PGC-1α is not exclusively required, and additional factors must be involved in the regulation of both basal expression and exercise-induced adaptations. Exercise-induced PGC-1α expression and potentially increased PGC-1α activity are likely the mechanisms contributing to skeletal muscle mitochondrial adaptations and concomitant health beneficial effects of regular physical activity.