慢性肾功能衰竭患者尿白细胞介素-6的检测及大黄对其影响 |
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引用本文: | 宋海翔,王子芬,张凤芳,周慧.慢性肾功能衰竭患者尿白细胞介素-6的检测及大黄对其影响[J].中国中西医结合杂志,2000,20(2):107-109. |
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作者姓名: | 宋海翔 王子芬 张凤芳 周慧 |
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作者单位: | 山东省临沂市中医医院!山东276002 |
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摘 要: | 目的:观察慢性肾功能衰竭(CRF)患者尿白细胞介素6(IL-6)变化的临床意义及大黄对尿IL-6的影响。方法:治疗组口服制大黄和卡托普利,对照组单服卡托普利,治疗6个月,观察治疗前后尿IL-6和血肌酐(SCr)等指标的变化。结果:CRF患者尿IL-6的含量显著高于健康人(P〈0.01);用大黄治疗后尿IL-6和SCr显 著下降(P〈0.05),与对照组治疗后比较有显著性差异(P〈0.05)。结论:检
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关 键 词: | 大黄 慢性 肾功能衰竭 白细胞介素6 |
Investigation of Urinary Interleukin 6 Level in Chronic Renal Failure Patients and The Influence of Rheum Palmatum in Treating It |
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Authors: | SONG Haixiang WANG Zifen ZHANG Fengfang Linyi Municipal TCM Hospital Shandong |
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Abstract: | To assess the clinical significance of urinary interleukin 6 (IL 6) level in chronic renal failure (CRF) patient and the effect of Rheum palmatum (RP) in treating it. Methods: RP and captopril were given to the study group, while captopril was given to the control group alone, and level of urinary IL 6 was determined by sandwich ELISA. Results: Urinary IL 6 level in CRF patients was obviously higher than that in healthy control (P<0 01). After treatment, the urinary IL 6 and serum creatinine reduced significantly in the study group (P<0 05), and there was significant difference compared with that in the control group (P<0 05). Conclusions: Determination of urinary IL 6 level is useful in studying the severity of immune inflammation of CRF. RP improves renal function by inhibiting the production of IL 6 and lowering immune inflammation. |
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Keywords: | Rheum palmatum chronic renal failure interleukin 6 |
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