梅毒合并HIV感染43例临床特征分析

目的分析梅毒合并艾滋病病毒（HIV）感染者的临床特征，了解其治疗效果。方法对武义县疾病预防控制中心诊治的43例梅毒合并HIV感染病例的资料做回顾性分析。结果43例病例中，显性梅毒占65．12％、隐性梅毒占34．88％。显性一期梅毒硬下疳大多不典型，可出现多个形态不一的溃疡面。二期梅毒疹皮损较非HIV感染者严重、复杂。经抗梅毒治疗后梅毒甲苯胺红不加热血清学试验（TRUST）阳性的转阴率低，持续时间长，血清固定比例增加。结论梅毒合并HIV感染会加重病情，增加治疗难度。临床工作中必须对所有梅毒患者或HIV感染者同时作梅毒血清学检查和HIV抗体筛查，避免误诊、漏诊。

Clinical analysis of 43 syphilis and HIV co-infected patients

Objective To investigate the clinical characteristics of syphilis patients with human immunodeficiency virus （HIV） co-infection and analyze their treatment effects. Method A retrospective analysis was conducted on 43 cases of syphilis patients with HIV con-infection diagnosed by center for disease control and prevention of Wuyi county. Results Among these cases, dominant syphilis accounted for 65.12% and latent syphilis for 34.88%. The hard chancre symptom was atypical in primary syphilis, showing multiple ulcers with varied shapes. In secondary syphilis, the skin lesion of syphiloderma was more serious and complex than that in non-HIV-infected patients. The negative conversion ratio of TRUST was low after antisyphilis therapy. TRUST remained positive for a long time and the rate of sero-resistance increased. Conclusion Syphilis and HIV co-infected patients may worsen the illness, which will increase the difficulty of therapy. Therefore, it is necessary to avoid misdiagnosis and missed diagnosis by carrying out syphilis and HIV screening tests among syphilis patients or HIV infected patients in clinical work.