奥沙利铂联合亚叶酸钙和氟尿嘧啶方案治疗老年人胃肠道肿瘤临床观察

 目的 观察奥沙利铂（L-OHP，商品名：艾恒）联合亚叶酸钙（CF）和氟尿嘧啶（5-Fu）即改良FOLFOX方案治疗老年人胃肠道肿瘤的疗效和毒性反应。方法 34例老年人胃肠道肿瘤，其中胃癌15例，大肠癌19例。给予改良FOLFOX方案，L-OHP 130 mg／m2静脉滴注4 h，第1天；CF 200 mg／m2静脉滴注2 h，第1 ~ 5天；5-Fu 500 mg／m2静脉滴注，第1 ~ 5天。每3周1个疗程，至少用3个疗程。结果 全组患者总有效（CR+PR）率44.1 %，其中胃癌总有效率40.0 %，大肠癌总有效率47.4 %，两组比较差异无统计学意义（P＞0.05）。中位缓解时间8.6个月，中位生存期11.2个月，1 年生存率52.2 %。主要毒副反应为白细胞减少，感觉神经毒性。结论 改良FOLFOX方案治疗老年人胃肠道肿瘤有效率较高，毒副反应轻。

Clinical study of the modified regimen of Oxaliplatin (L-OHP) combined with Calcium folinate(CF) and 5-Fluorouracil(5-Fu) for old patients with gastrointestinal carcinoma

Objective To observe the curative effect and toxicity of the modified regimen of oxali－platin (L-OHP) combined with calcium folinate (CF) and 5-fluorouracil (5-Fu) in the treatment of old pati－nants with gastrointestinal carcinoma. Method 34 old patients gastrointestinal carcinoma (15 cases gastric cancer, 19 cases colon cancer) received chemotherapy of modified FOLFOX regimen: L-OHP 130 mg/m2 was given on 1st day intravenous infusion, CF 200 mg/m2 and 5-Fu 600 mg/m2 was given on 1st to 5th day intra－venous infusion, every 3 weeks as 1 cycle, tumor assessment was done after 3 cycles. Results Among 34 pat－ints, the overall response rate(CR+PR) was 44.1 %, gastric cancer response rate was 40.0 % and colon cancer response rate was 47.4 %. Significant difference was no satistically between the two groups (P >0.05). Median response time was 8.6 months. Median survival time was 11.2 months. the 1 year survival rate was 52.2 %. The main side effect include leukopenia, sensory neuritis. Conclusions The modified regimen of oxaliplatin (L-OHP) combined with calcium folinate (CF) and 5-fluorouracil (5-Fu) is an active and tolerable regimen for old patients with gastrointestinal carcinoma.