| Rutaecarpine衍生物的合成及体外抗血小板聚集活性 |
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| 引用本文： | 刘青,郑伟,桑海婴,陈建兴. Rutaecarpine衍生物的合成及体外抗血小板聚集活性[J]. 中国药物化学杂志, 2006, 16(1): 20-22 |
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| 作者姓名： | 刘青 郑伟 桑海婴 陈建兴 |
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| 作者单位： | 1. 国家新药筛选中心,上海,201203
2. 上海市计划生育科学研究所,药物研究室,上海,200032 |
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| 摘 要： | 目的合成新的rutaecarpine衍生物并对其抗血小板聚集活性进行研究。方法先合成rutaecarpine,再进行N-取代反应,合成目标化合物,并测试所合成化合物的体外抗血小板聚集活性。结果与结论共合成6个未见文献报道的新化合物,它们的结构经1H-NMR和MS确证。初步体外药理实验结果显示:有4个新化合物对血小板聚集的抑制作用强于母体化合物rutaecarpine。
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| 关 键 词： | 药物化学 化合物制备 化学合成 rutaecarpine衍生物 抗血小板聚集 |
| 文章编号： | 1005-0108（2006）01-0020-03 |
| 收稿时间： | 2005-09-19 |
| 修稿时间： | 2005-09-19 |
Synthesis and anti-platelet aggregation activities in vitro of rutaecarpine derivatives |
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| LIU Qing,ZHENG Wei,SANG Hai-ying,CHEN Jian-xing. Synthesis and anti-platelet aggregation activities in vitro of rutaecarpine derivatives[J]. Chinese Journal of Medicinal Chemistry, 2006, 16(1): 20-22 |
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| Authors: | LIU Qing ZHENG Wei SANG Hai-ying CHEN Jian-xing |
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| Affiliation: | 1. The National Center for Drug Screening, Shanghai 201203, China ; 2. Department Drug Research, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China |
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| Abstract: | Aim To design and synthesize new rutaecarpine derivatives,and to evaluate their activities of anti-platelet aggregation.Methods Rutaecarpine was prepared,then the target compounds were synthesized from rutaecarpine via N-substitution.Their anti-platelet aggregation activities were determined in vitro.Results and conclusions Six derivatives of rutaecarpine were synthesized with the structures confirmed by their()~1H-NMR and MS spectra.The primary pharmacological test in vitro shows that the anti-platelet aggregation activities of four new derivatives are higher than that of rutaecarpine. |
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| Keywords: | medicinal chemistry compound preparation chemical synthesis rutaecarpine derivatives anti-platelet aggregation |
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