15岁以下人群乙型肝炎病毒感染及免疫现状调查分析 |
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引用本文: | 陈瑚瑚,张鹏举,张小兵,刘艳艳.15岁以下人群乙型肝炎病毒感染及免疫现状调查分析[J].甘肃医药,2014,0(8):573-575. |
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作者姓名: | 陈瑚瑚 张鹏举 张小兵 刘艳艳 |
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作者单位: | 陈瑚瑚 (静宁县疾病预防控制中心免疫规划科, 甘肃 平凉,743400); 张鹏举 (静宁县疾病预防控制中心免疫规划科, 甘肃 平凉,743400); 张小兵 (静宁县疾病预防控制中心免疫规划科, 甘肃 平凉,743400); 刘艳艳 (静宁县疾病预防控制中心免疫规划科, 甘肃 平凉,743400); |
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摘 要: | 目的:了解静宁县15岁以下人群乙肝疫苗接种现状、乙肝病毒标志物的分布情况及影响因素,为采取进一步控制措施提供依据。方法:采取整群分层随机抽样的方法,抽取本辖区7个乡镇的15岁以下的1260人作为调查对象,检测HBsAg、抗-HBs、抗-HBc等HBV感染标志物,以问卷和查验预防接种证或卡片的方式对乙肝疫苗接种率进行调查。结果:15岁以下人群HBsAg、抗-HBs和抗-HBc阳性率分别为0.95%、78.97%、5.16%,HBV感染率为6.98%。HBsAg、抗-HBc阳性率和HBV感染率随年龄增长而升高(P〈0.05)。15岁以下人群乙肝疫苗全程接种率为90.95%,随年龄的增加而逐渐降低(χ2趋势=60.569,P=0.000)。结论:15岁以下人群HBV感染率已处于较低水平,乙肝保护性抗体水平随年龄的减小而升高;乙肝疫苗接种是乙肝病毒感染的保护因素,年龄是乙肝病毒感染的危险因素。
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关 键 词: | 乙肝病毒标志物 血清流行病学 影响因素 乙肝疫苗 |
Study of distribution of hepatitis B virus infection and immunization on children under 15 years old |
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Authors: | CHEN Hu-hu ZHANG Peng-ju ZHANG Xiao-bing LIU Yan-yan |
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Institution: | ( Department of Immune Programming, Center for Diseases Prevention and Control in Jingning County, Pingliang 743400,China) |
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Abstract: | Distribution and relative fators of hepatitis B vaccination and marker of hepatitis B virus were observed in children under 15 years old, which provide scientific data for prevention. Methods:Cluster sampling and stratified random sampling were used to selected 1260 individuals under 15 years old from 7 towns for study in which HBsAg, anti-HBs, anti-HBc and other HBV infection markers were respectively detected,and questionnaire investigation, examination of vaccination certificate or card were used to assess hepatitis B vaccination rate. Results:HbsAg, anti-HBs, anti-HBc positive rates and HBV infection rate in children under 15 years old respectively were 0.95%, 78.97%, 5.16%and 6.98%, which was increased with age(P〈0.05). Hepatitis B vaccine coverage rate was 90.95%, which was reduced with age(χ2=60.596, P=0.000). Conclusion:HBV infection rate is a lower level in children under 15 years old. Levels of protective antibodies to hepatitis B are reduced with age. Hepatitis B vaccination is a protective factor for hepatitis B virus infection, but age is a risk factor. |
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Keywords: | hepatitis B virus markers seroepidemiology relative factors hepatitis B vaccine |
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