| P27Kip1和CyclinD1在膀胱移行细胞癌中的表达 |
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| 引用本文： | 刘学锋,吴斌. P27Kip1和CyclinD1在膀胱移行细胞癌中的表达[J]. 中国现代医学杂志, 2006, 16(7): 1013-1015 |
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| 作者姓名： | 刘学锋 吴斌 |
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| 作者单位： | 中国医科大学附属第二医院,泌尿外科,辽宁,沈阳,110004 |
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| 摘 要： | 目的 研究膀胱移行细胞癌（BTCC）中P27Kip1和CyclinD1的表达，探讨与膀胱癌生物学特征的内在联系。方法 应用免疫组化S-P法，对51例BTCC及6例正常膀胱组织中P27Kip1和CyclinD1进行检测。结果 P27kip1和CyclinD1在BTCC不同临床分期，不同病理分级中表达阳性率差异显著，P〈0．05。结论 P27Kip1和CyclinD1在BTCC中的表达与肿瘤生物学行为密切相关。
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| 关 键 词： | 膀胱癌 |
| 文章编号： | 1005-8982（2006）07-1013-03 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005-05-23 |
Expression of P27Kip1 and CyclinD1 in bladder tumor |
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| LIU Xue-feng,WU Bin. Expression of P27Kip1 and CyclinD1 in bladder tumor[J]. China Journal of Modern Medicine, 2006, 16(7): 1013-1015 |
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| Authors: | LIU Xue-feng WU Bin |
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| Affiliation: | Department of Urology, the Second Affiliated Hospital, China Medical University, Shenyang, Liaoning 110004, P.R.China |
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| Abstract: | Objective To evaluate the expression of P27kip1 and Cyclin D1 in human transitional cell carcinoma of bladder(BTCC). To study the association between the biological characteristics of BTCC and P27kip1 and Cyclin D1. Methods The expression of P27kip1 and Cyclin D1 was detected by SP immunohistochemical technique in 51 BTCC and 6 cases of normal bladder tissue. Results The positive expression of P27kip1 and CyclinD1 in BTCC are closely correlated with different pathological grade and clinical stage (P <0.05). Conclusion The expression of P27kip1 and Cyclin D1 closely correlates with biological behavior of BTCC. |
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| Keywords: | P27Kip1 CyclinD1 |
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