Quantitative Assessment of Intracanal Regenerated Tissues after Regenerative Endodontic Procedures in Mature Teeth Using Magnetic Resonance Imaging: A Randomized Controlled Clinical Trial |
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| Affiliation: | 1. Conservative Department, Endodontic Division, Faculty of Dentistry, Alexandria University, Alexandria, Egypt;2. Radiology and Medical Science Department, Faculty of Allied Science, Pharos University, Alexandria, Egypt;1. Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan;2. Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil;3. Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;4. Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil;1. Advanced Specialty Education Programs in Endodontics, School of Dentistry, Loma Linda University, Loma Linda, California;2. Department of Endodontics, UCLA School of Dentistry, Los Angeles, California;3. Department of Advanced Oral Sciences and Therapeutics, Division of Endodontics, School of Dentistry, University of Maryland, Baltimore, Baltimore, Maryland;4. Advanced Specialty Education Programs in Oral and Maxillofacial Surgery, School of Dentistry, Loma Linda University, Loma Linda, California;1. Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan;3. Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan;4. Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Michigan;2. Private Practice, Jackson, Michigan;1. Department of Stem Cell Biology and Regenerative Medicine, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan;2. Department of Endodontology, School of Dentistry, Aichi-gakuin University, Nagoya, Japan;3. Department of Oral and Maxillofacial Radiology, School of Dentistry, Aichi-gakuin University, Nagoya, Japan;4. Department of Aging Neurobiology, Center of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan;6. Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Japan;1. Centro de Investigación en Biología y Regeneración Oral, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile;2. Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile;3. Consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile;4. Cells for Cells, Santiago, Chile |
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| Abstract: | IntroductionThe present study quantitatively assessed tissue regeneration after regenerative endodontic procedures (REPs) with 2 different apical preparation sizes in mature teeth using magnetic resonance imaging (MRI).MethodsEighteen maxillary anterior mature necrotic teeth with periapical lesions were selected for the study. The teeth were randomly allocated into 2 groups. Canal preparation was performed using Protaper Next files (Dentsply Sirona, York, PA) until size X3 and X5 in the test and control groups, respectively. REPs were performed, and Biodentine (Septodont, Saint-Maur-des-Fossés, France) was used as the cervical plug material. In both groups, MRI was used to measure the signal intensity (SI) of the regenerated tissue at 3, 6, and 12 months at both the middle and the apical thirds of the canal. The SI between the normal contralateral teeth and each successive interval was compared. Clinical examination, sensibility tests, and digital periapical radiographs were also performed at successive time intervals. Statistical analysis was performed using the Student t test and Cochran test. The level of significance was set at P ≤ .05.ResultsAll 18 teeth were symptom free with healing of the periapical lesions. Regarding the SI measurements, there was no statistically significant difference between the SI of the normal contralateral teeth and that of the regenerated tissues in the treated teeth after a 12-month follow-up. In both groups, more than 60% of the cases regained pulp sensibility after 12 months.ConclusionsVital pulplike tissue could be successfully regenerated in mature teeth using REPs, which was not significantly affected by the size of the apical diameter. MRI could successfully assess this tissue in a quantitative, noninvasive manner. |
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| Keywords: | Magnetic resonance imaging mature teeth necrotic teeth regenerative endodontic procedures |
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