| 黄体酮对脑梗死大鼠脑部MMP-9、TIMP-1表达及血脑屏障通透性的影响 |
| |
| 引用本文： | 郝玉金,王建平,刘春岭,李昕,蒋超,陈宁宁. 黄体酮对脑梗死大鼠脑部MMP-9、TIMP-1表达及血脑屏障通透性的影响[J]. 中国实用神经疾病杂志, 2010, 13(1): 11-13 |
| |
| 作者姓名： | 郝玉金 王建平 刘春岭 李昕 蒋超 陈宁宁 |
| |
| 作者单位： | 1. 郑州大学第二附属医院神经内科,郑州,450014
2. 郑州大学第五附属医院,郑州,455000 |
| |
| 摘 要： | 目的观察黄体酮对脑梗死大鼠脑组织MMP-9、TI MP-1表达及血脑屏障通透性的影响。方法制作SD大鼠永久性局灶性脑缺血模型(permanent middle cerebral arteryocclusion,pMCAO),将大鼠随机分成假手术组、模型组、HBC溶剂治疗组和黄体酮治疗组。模型组、HBC溶剂治疗组和黄体酮治疗组,其中后3组设24h、48h、7d 3个时间点,每组每个时间点12只。应用干湿重法检测脑组织含水量;免疫组织化学法研究脑组织MMP-9、TI MP-1的表达情况。结果模型组MMP-9、TI MP-1的表达及脑水含量在各个时间点与HBC溶剂治疗组相比差异无统计学意义(P0.05),但在黄体酮治疗组脑组织中的表达较模型组和HBC治疗组明显降低(P0.05)。结论黄体酮可能通过调节MMP-9/TI MP-1表达,降低血脑屏障通透性,减轻脑缺血后脑水肿程度。
|
| 关 键 词： | 脑缺血 黄体酮 基质金属蛋白酶-9 金属蛋白酶组织抑制剂-1 血脑屏障 |
Effect of progesterone on the expression of MMP-9 and TIMP-1 and blood-brain barrier permeability after focal cerebral permanent ischemia in rats |
| |
| Hao Yujin,Wang Jianping,Liu Chunling,et al. Effect of progesterone on the expression of MMP-9 and TIMP-1 and blood-brain barrier permeability after focal cerebral permanent ischemia in rats[J]. Chinese Journal of Practical Neruous Diseases, 2010, 13(1): 11-13 |
| |
| Authors: | Hao Yujin Wang Jianping Liu Chunling et al |
| |
| Affiliation: | Hao Yujin,Wang Jianping,Liu Chunling,et al.Department of Neurology of the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China |
| |
| Abstract: | Objective To study the effects of progesterone on the expression of MMP-9(matrix metalloproteinase-9,MMP-9) and TIMP-1(tissue inhibitor of metalloproteinase-1,TIMP-1) and blood-brain barrier permeability in cerebral ischemia in rats.Methods Permanent middle cerebral arteryocclusion rats model(pMCAO) was used in this experiment.All rats were randomly divided into 4 groups: the progesterone treated group,the HBC treated group,the model group and the sham operated group.Except for shamed operated group,12 rats... |
| |
| Keywords: | Cerebral ischemia Blood brain barrier Progesterone Matrix metalloproteinase-9 Tissue inhibitor of metalloproteinase-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
