| 一株连翘内生真菌代谢粗提物对胃癌细胞株MGC-803增殖的影响 |
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| 引用本文： | 江苏安,刘文洪,梁栋娥,蒋永生,张贝贝. 一株连翘内生真菌代谢粗提物对胃癌细胞株MGC-803增殖的影响[J]. 中华中医药学刊, 2013, 0(11): 2505-2506,I0007 |
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| 作者姓名： | 江苏安 刘文洪 梁栋娥 蒋永生 张贝贝 |
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| 作者单位： | [1]淳安县第一人民医院,浙江淳安311700 [2]浙江中医药大学,浙江杭州310053 [3]浙江工业大学,浙江杭州310014 |
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| 基金项目： | 国家自然科学基金资助项目（31270051）;浙江省教育厅重点项目（Z201121522）;浙江省科技厅浙江省公益技术应用研究项目（2011C21034）;浙江省自然科学基金资助项目（Y2101290） |
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| 摘 要： | 目的：评价一株连翘内生真菌代谢粗提物体外对胃癌细胞株MGC-803增殖的影响，为寻找临床胃癌治疗新药提供思路。方法：采用常规分离手段分离得到连翘内生真菌26株，应用MTT法测定其发酵代谢产物粗提物对MGC-803增殖的影响。结果：MGC-803经内生真菌FS12的发酵代谢产物粗提物FE-12作用后细胞克隆受到明显的抑制，且在时间和剂量上存在一定的依赖性。结论：连翘内生真菌FS12的发酵粗提物FE-12可抑制胃癌细胞株MGC-803增殖，为寻找临床胃癌治疗新药提供了一条新的思路。
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| 关 键 词： | 连翘 内生真菌 MGC-803 增殖 |
Influence to MGC -803 by Crude Extract of Endophytic Fungus from Forsythia suspensa |
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| JIANG Su＇ an,LIU Wenhong,LIANG Dong＇ e,JIANG Yongsheng,ZHANG Beibei. Influence to MGC -803 by Crude Extract of Endophytic Fungus from Forsythia suspensa[J]. Chinese Archives of Traditional Chinese Medicine, 2013, 0(11): 2505-2506,I0007 |
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| Authors: | JIANG Su＇ an LIU Wenhong LIANG Dong＇ e JIANG Yongsheng ZHANG Beibei |
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| Affiliation: | ( First People Hospital of Chun＇ an County, Chunn 311700, Zhejiang, China ; 2. Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China; 3. Zhejiang University of Technology, Hangzhou 310014,Zhejiang, China) |
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| Abstract: | Objective ： To evaluate the influence to MGC - 803 by the crude extract of an endophydc fungus from For- sythia suspensa, hoping to find a new way for looking for new drugs for treating gastric cancer. Methods ： Isolate endophytic fungi from Forsythia suspensa was obtained via conventional separation means, using MTT method to determine the activi- ties of the metabolites against MGC -803. Results ：The metabolite from the endophytic fungus FS12 proved an obvious in- hibition to the cell cloning of MGC - 803, and it showed some dependence on time and dose. Conclusion ： The crude extract of FS12 inhibits the proliferation of MGC - 803, providing a new idea of finding new drugs for treating gastric cancer. |
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| Keywords: | Forsythia suspensa endophytic fungi MGC - 803 proliferation |
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