含丹参腹膜透析液对微炎症状态的干预作用

目的：观察维持性腹膜透析（CAPD）患者微炎症状态，探讨丹参对微炎症的影响。方法：38例CAPD患者随机分为对照组（常规透析）和治疗组（常规透析加丹参），分别测定各组基础以及透析3月后微炎症指标：白介素-6（IL-6），肿瘤坏死因子-α（TNF-α），超敏C反应蛋白（hs—CRP）以及血尿素氮（BUN）、血肌酐（Scr）、血清白蛋白（ALB）、血红蛋白（Hb）等。结果：（1）透析患者的hs—CRP、IL-6、TNF—α明显高于正常健康人；（2）治疗组患者3月后血清炎症因子hs—CRP、IL-6、TNF-α水平均降低（P〈0．05）；两组治疗后比较，差异有统计学意义（P〈0．05）；（3）两组患者治疗后血尿素氮（BUN）、血肌酐（Scr）、血清白蛋白（ALB）、血红蛋白（Hb）水平稳定，无明显变化（P〉0．05）。两组治疗后比较，差异无统计学意义（P〉0．05）。结论：CAPD患者普遍存在微炎症状态．丹拳可有效地短期改善CAPD患者的微炎症状态．但对改善腹膜溶质转运功能无意义。

Impacts of Danshen on Microinflammation in Peritoneal Dialysis Patients

Objective：To investigate the state of microinflammation in continuous ambulatory peritoneal dialysis （CAPD）patients and the impacts of Danshen on it. Methods ：38 CAPD patients were divided into control group（ no Dan- shen addition）and experimental group（ with Danshen in peritoneal fluid）, Interleukin -6 （IL- 6 ）, Tumour necrosis factor - α （ TNF - α）, C - reactive protein （CRP） , blood urea nitrogen （ BUN ）, serum creatinine （ Scr）, albumin （ ALB ） and he- moglobin （Hb） were observed before and 3 months after peritoneal dialysis. Result ： The blood levels of IL - 6, TNF - αand CRP were higher in CAPD patients than that in the normal people. Three months after peritoneal dialysis, the blood levels of IL- 6 ,TNF -αand CRP were degraded in experimental group（ P 〈 0.05 ） , and there was significant differences be- tween the two groups（ P 〈 0.05 ）. The blood levels of BUN, Scr, ALB and Hb were stable（ P 〉 0.05 ）, and there was no significant differences between them（ P 〉 0.05 ）. Conclusion：Microinflammation is universal in CAPD patients. Danshen can ameliorate the state of microinflammation, but it is of no use in improving peritoneal transport function.