| 应用CLSM对自体表皮移植治疗白癜风的疗效观察 |
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| 引用本文： | 罗卫,;马春林,;吕俊卿,;蔡瑞康.应用CLSM对自体表皮移植治疗白癜风的疗效观察[J].西南国防医药,2014(5):513-515. |
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| 作者姓名： | 罗卫 ;马春林 ;吕俊卿 ;蔡瑞康 |
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| 作者单位： | [1]解放军空军总医院皮肤科,北京100142; [2]北京方舟白癜风医院,北京100142; |
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| 摘 要： | 目的应用共聚焦激光扫描显微镜（CLSM）观察自体表皮移植治疗白癜风后的黑素细胞恢复状况。方法采用CLSM对白癜风皮损进行检测,选择镜下显示黑素细胞完全消失的皮损进行自体表皮移植,移植后1、3、6个月动态观察黑素细胞恢复状况。结果 20例白癜风患者中,28块皮损进行了自体表皮移植,临床总成活率为96.43%,移植后CLSM成像显示黑素细胞完全恢复率为82.14%。结论 CLSM检测可作为白癜风自体表皮移植治疗适应证的选择方法,也可作为移植治疗后连续动态观察黑素细胞恢复状况的可靠手段。
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| 关 键 词： | 共聚焦激光扫描显微镜 白癜风 表皮移植 黑素细胞 |
Application of CLSM to observesion of curative effect of autologous epidermal grafting on vitiligo |
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| Institution: | Luo Wei , Ma Chunlin, Lu Junqing, Cai Ruikang( 1. Department of Dermatology, Air Force General Hospital of PLA, Beijing, 100142, China ;2. Fangzhou Vitiligo Hospital, Beijing, 100022, China) |
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| Abstract: | Objective To observe the changes of melanocytes in vitiligo after autologou epidermal grafting under confocal laser scanning microscope（ CLSM）. Methods CLSM was applied to detect the skin lesions of vitiligo; the lesions without melanocytes under CLSM were selected for autologou epidermal grafting and dynamic observation under CLSM was made for the changes of melanocytes 1,3 and 6 months after grafting. Results 28 lesions in 20 cases with vitiligo were performed autologou epidermal grafting; the total clinical survival rate was 96. 43%; the full recovery of melanocytes on CLSM imaging after grafting reached 82. 14%. Conclusions CLSM detection can help the indication selection of autologous epidermal grafting for vitiligo and it is a reliable method of dynamic observation of melanocyte recovery after grafting. |
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| Keywords: | confocal laser scanning microscope（CLSM） vitiligo epidermal grafting melanocyte |
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