药物治疗对高血压患者臂踝脉搏传导速率的影响

目的探讨药物治疗对高血压患者臂踝脉搏波传导速率（baPWV）的影响。方法选取2012年12月～2013年12月在我院健康体检并确诊为高血压的患者129例,根据用药情况分为安博维组（34例）、代文组（25例）、络活喜组（29例）、洛汀新组（23例）和未用药组（18例）,比较5组心率、血压、脉压差和baPWV的差异。结果使用降压药的高血压患者,收缩压、舒张压、脉压和baPWV与未用药患者存在统计学差异（P〈0.01）,心率则无统计学差异。药物治疗的4组收缩压、舒张压和脉压无统计学差异（P〉0.05）。安博维组、代文组、络活喜组、洛汀新组和未用药组的baPWV分别为（1566.2±335.0）、（1589.8±288.6）、（1519.5±198.4）、（1702.3±517.5）和（1858.1±341.3）cm/s,组间比较均存在统计学差异（P〈0.05）。结论4种降压药物均可以有效降低高血压患者的血压,然而其改善动脉弹性功能效果不同,其中络活喜的改善效果最为显著。

Effects of antihypertensive medicines on brachia-ankle pulse-wave velocity of hypertension patients

Objective To explore the effects of antihypertensive medicines on brachia-ankle pulse-wave velocity of hypertension patients.Methods Total 129 patients who received health examination and were diagnosed as hypertension in our hospital from Dec.of 2012 to Dec.of 2013 were selected.According to the medicines they took,these subjects were divided into Aprovel group（n= 34）,Diovan group（n = 25）,Norvasc group（n = 29）,Lotensin group（n = 23）and untreated group（n = 18）;and then,the differences in heart rate,blood pressure,pulse pressure and baPWV were compared among 5 groups.Results The systolic pressure,diastolic pressure,pulse pressure and baPWV of the patients taking antihypertensive medicines were significantly different from those of the untreated patients（P〈0.01）,while there was no significant difference in heart rate.Among the 4 groups of patients receiving medicine treatment,the systolic pressure,diastolic pressure and pulse pressure had no significant difference（P〉0.05）.The baPWV of the 5groups of patients was（1566.2 ± 335.0）,（1589.8 ± 288.6）,（1519.5 ± 198.4）,（1702.3 ± 517.5） and（1858.1 ± 341.3） cm /s,respectively,and there were differences among 5 groups（P〈0.05）.Conclusion Above four antihypertensive medicines can reduce effectively the blood pressure of hypertensive patients,but their effect in improving the function of arterial elasticity is different and the effect of Norvasc is the most remarkable comparatively.