怀孕对甲状腺微小乳头状癌进展影响的相关研究

目的探讨怀孕对甲状腺微小乳头状癌进展的影响。方法选择2000年1月～2013年12月12例孕期诊断为甲状腺微小乳头状癌的患者,同时选取20例非孕期的甲状腺微小乳头状癌的患者作为对照。随访期间监测肿瘤大小、Tg以及TSH的水平变化。结果孕期甲状腺微小乳头状癌患者的肿瘤大小由诊断时（6.2±2.1）mm增长至产后6个月的（9.2±4.4）mm,此时显著大于对照组肿瘤大小（6.9±4.5）mm,P〈0.05]。甲状腺微小乳头状癌患者Tg水平在孕中期为（33.59±10.23）ng/ml,显著高于诊断时水平（12.34±4.23）ng/ml,P〈0.05]；TSH水平在孕中期为（0.3±0.1）μIU/ml,也显著高于诊断时水平（3.5±1.2）μIU/ml,P〈0.05]。结论怀孕期间,甲状腺微小乳头状癌患者的肿瘤显著增大,Tg及TSH水平显著增高。因此,对甲状腺微小乳头状癌患者应该密切随访,尤其是在孕早期。

Impact of pregnancy on the progress of thyroid papillary micorcarcinoma

Objective To discuss the impact of pregnancy on thyroid papillary microcarcinoma.Methods 12 patients with thyroid papillary microcarcinoma in pregnancy and 20 female patients with thyroid papillary microcarcinoma as the control were enrolled in this study;the size of the tumors,the levels of Tg and TSH in all the cases was monitored in follow-up. Results The size of tumors significantly enlarged（ 6. 2 ± 2. 1） mm vs（ 9. 2 ± 4. 4） mm,P 0. 05] during pregnancy; the level of Tg increased during middle pregnancy（ 33. 59 ±10. 23） ng/ml vs（ 12. 34 ± 4. 23） ng/ml,P 〈0. 05]; and the same change was detected in the level of TSH（ 0. 3 ± 0. 1） μIU/ml vs（ 3. 5 ±1. 2） μIU/ml,P〈 0. 05]. Conclusions The size of the tumor gets enlarged greatly in patients with thyroid papillary microcarcinoma in pregnancy and the levels of Tg and TSH rise up; a careful follow-up should be made,especially during early pregnancy.