大剂量阿托伐他汀对ACI神经功能恢复及复发率的影响

目的观察大剂量阿托伐他汀对急性脑梗死（ACI）患者血脂、神经功能恢复情况及1年复发率的影响。方法120例发病72 h内入院的ACI患者随机分为2组,口服阿托伐他汀20 mg/d组（对照组）和40 mg/d组（治疗组）各60例,观察治疗前和治疗4 w后患者血脂水平,用美国国立卫生研究所脑卒中评分（NIHSS）评定患者神经功能缺损程度,观察治疗1年后患者生活能力Barthel指数（BI）、脑缺血事件复发率。结果治疗4 w后,两组血脂水平、神经功能缺损程度较治疗前明显好转（P〈0.01）,但治疗组均明显优于对照组（P〈0.01）。1年后生活能力BI指数、复发率,两组均较治疗前明显改善（P〈0.01）,治疗组改善明显优于对照组（P〈0.05）。结论大剂量阿托伐他汀治疗ACI,可更有效地降低血脂水平,促进神经功能恢复,提高患者的生活能力,并降低脑缺血事件复发率。

Efficacy of high-dose atorvastatin in nervous functional rehabilitation in patients with acute cerebral infarction and recurrence rate

Objective To observe the efficacy of high-dose atorvastatin in nervous functional rehabilitation in patients with acute cerebral infarction（ ACI） and 1-year recurrence rate. Methods 120 cases suffered from ACI in 72 h were randomly divided into2 groups： conventional-dose atorvastatin treatment group（ control group,20 mg /d） and high-dose atorvastatin treatment group（ treatment group,40 mg /d）,60 cases in each group. Before and after 4 weeks treatment,their blood lipid level was measured and the degree of neurological deficits was evaluated with the U. S. National Institutes of Health Stroke Score（ NIHSS）. The Barthel index（ BI） and cerebral ischemic event recurrence rate were observed after one year. Results The level of blood lipid and the degree of neurological deficits in both groups were significantly better after 4 weeks treatment than those before treatment（ P〈0. 01）; BI and the recurrence rate in both groups after one year were significantly better than those before treatment（ P〈0. 01）. The therapeutic effect was better in the treatment group than that in the control group（ P〈0. 05）. Conclusions High-dose atorvastatin has a good effect on ACI and can reduce 1-year recurrence rate.