| 甲磺酸帕珠沙星原料药的急性毒性作用研究 |
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| 引用本文： | 章伟,吴友良,赵小风. 甲磺酸帕珠沙星原料药的急性毒性作用研究[J]. 中国药业, 2007, 16(15): 16-17 |
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| 作者姓名： | 章伟 吴友良 赵小风 |
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| 作者单位： | 中国人民解放军第324医院药剂科,重庆,400020 |
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| 摘 要： | 目的 研究甲磺酸帕珠沙星原料药的急性毒性作用,指导临床安全用药.方法 按照〈化学药物急性毒性试验技术指导原则〉中方法进行试验.结果 甲磺酸帕珠沙星原料药小鼠一次性灌胃最小致死量（MLD）大于5000mg/kg,小鼠静脉注射半数致死量（LD50）为439.35mg/kg,95%可信限为399.99～482.58 mg/kg.结论 甲磺酸帕珠沙星毒性小,使用安全范围大.
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| 关 键 词： | 甲磺酸帕珠沙星 急性毒性 半数致死量 |
| 文章编号： | 1006-4931（2007）15-0016-02 |
| 修稿时间： | 2007-04-16 |
Research on Acute Toxicity of Pazufloxacin Mesilate''''s Raw Material |
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| Zhang Wei,Wu Youliang,Zhao Xiaofeng. Research on Acute Toxicity of Pazufloxacin Mesilate''''s Raw Material[J]. China Pharmaceuticals, 2007, 16(15): 16-17 |
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| Authors: | Zhang Wei Wu Youliang Zhao Xiaofeng |
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| Affiliation: | Department of Pharmacy, No. 324 Hospital of PLA, Chongqing, China 400020 |
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| Abstract: | Objective To study the acute toxicity of pazufloxacin mesilate's raw material.Methods According to the method in Guiding Principle of Chemical Medicine's Acute Toxicity,the test was performed.Results Mice were divided into two groups.One group were poured the raw material of pazufloxacin mesilate with forece into stomaches,the MLD was more than 5 000 mg/kg.The other group were given by vein injection,the LD50 was 439.35 mg/kg.And 95% confidence interval was 399.99-482.58 mg/kg.Conclusion The toxicity of pazufloxacin mesilate is small.It is safe and can be applied widely. |
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| Keywords: | pazufloxacin mesilate acute toxicity LD50 |
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