Epigenetic change in e-cardherin and COX-2 to predict chronic periodontitis |
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| Authors: | Wings TY Loo Lijian Jin Mary NB Cheung Min Wang Louis WC Chow |
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| Institution: | 1.Faculty of Dentistry,The University of Hong Kong,Hong Kong,China;2.Keenlink Dental Clinic,Hong Kong,China;3.State Key Laboratory for Oral Diseases and Department of Prosthodontics, West China College of Stomatology,Sichuan University,China;4.UNIMED Medical Institute and Organisation for Oncology and Translational Research Hong Kong,China |
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| Abstract: | Background DNA methylation of certain genes frequently occurs in neoplastic cells. Although the cause remains unknown, many genes have
been identified with such atypical methylation in neoplastic cells. The hypermethylation of E-Cadherin and Cyclooxygenase
2 (COX-2) in chronic inflammation such as chronic periodontitis may demonstrate mild lesion/mutation epigenetic level. This
study compares the hypermethylation status of E-Cadherin and COX-2 genes which are often found in breast cancer patients with
that in chronic periodontitis. |
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