Mécanismes moléculaires du syndrome néphrotique idiopathiqueMolecular basis of idiopathic nephrotic syndrome. |
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Authors: | G. Deschê nes,L. Martinat |
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Affiliation: | 1 Service de néphrologie pédiatrique, hôpital Armand-Trousseau, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France;2 service de pédiatrie générale, centre hospitalier Lucien-Hussel, 38200 Vienne, France |
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Abstract: | Steroid-sensitive idiopathic nephrotic syndrome is a T-cell disorder associated with a functional renal impairment. The molecular mechanisms leading from the stimulation of the immune system to the clinical expression of the renal disease can be analyzed according to five biological events: 1) a Th2 activation of T-cells by interleukin-13; 2) a yet unidentified glomerular permeability factor from immune origin; 3) a molecular disorientation of slit diaphragms or glomerular basement membrane responsible for proteinuria; 4) a podocyte cytoskeleton rearrangement responsible for foot process effacement; and 5) renal avidity for sodium and edema formation resulting from a primary stimulation of tubular Na,K-ATPase and an increase of endothelial permeability. |
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Keywords: | Mots-clé : syndrome né phrotique biologie molé culaireMots-clé : nephrotic syndrome, minimal change molecular biology review |
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