刺五加总皂苷对家兔血小板、凝血功能及血液流变性的影响

目的:刺五加总皂苷对家兔血小板、凝血功能及血液流变性的影响.方法:采用TYXN-96多功能智能血液凝聚仪和LBY-N6B型自清洗旋转式黏度计测定刺五加总皂苷对家兔血小板数和血小板聚集功能、部分凝血活酶时间(APTT)、凝血活酶时间(PT)、凝血酶时间(TT)及全血黏度、血浆黏度、红细胞压积的影响.结果:家兔静脉注射刺五加总皂苷0.5 mg/kg、1 ms/kg和2 mg/kg对ADP诱导的家兔血小板最大聚集率具有抑制作用,可显著降低家兔全血黏度(P＜0.01);对家兔血液APTT、PT、TT均无显著影响.结论:刺五加总皂苷具有改善家兔血液流变性、抑制血栓形成作用,而此作用是通过解聚红细胞聚集性、降低全血黏度完成的.

Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits

Objective:To study the effects of acanthopanax senticosus saponins (ASS)on platelet,blood coagulation and blood vis- cosity in rabbits.Methods:Platelet aggregation,APTT (activated partial thromboplastin time),PT (prothrombin time),TT (Thrombin time),blood viscosity,plasma viscosity and hematocrit were measured by mutifunctional intellectual blood coagulation analyzer and self erasure rotary viscometer after rabbit was fed with ASS.Results:ASS significantly inhibited platelet aggregation induced by ADP, and ASS can decrease the blood viscosity significantly.But it had no effect on APT1",PT and I3".Conclusion::ASS possessed the abili- ty of improving blood viscosity and inhibiting thrombosis.This effect was due to its action on decreasing erythrocyte aggregation and blood stickiness.